重庆地区2497例妇科就诊患者HPV感染状况分析

Investigation and analysis on HPV infection status of 2 497 patients with gynecological disease in Chongqing

目的:调查重庆市女性人群人乳头状瘤病毒(Human papillomavirus,HPV)感染状况,为预防HPV感染和宫颈癌防治提供理论依据。方法:采用HPV基因分型技术对2009年5月-2011年11月在重庆市妇幼保健院妇科门诊就诊的2 497例妇女进行HPV检查,分析HPV-DNA亚型感染状况。结果:2 497例患者中共检出HPV阳性者432例,阳性率为17.30%,其中高危型HPV感染阳性率为10.97%(274/2 497)。在被测的23个HPV-DNA亚型中,最常见类型依次为16型(32.18%,139/432),43型(18.75%,81/432),58型(15.05%,65/432),52型(13.19%,57/432),6型(8.56%,37/432),未检测出44型及MM4型。HPV阳性者中多重感染率为23.84%(103/432),以二重感染最常见(18.98%,82/432)。不同年龄段人群HPV阳性率有差异,50岁以上人群HPV阳性率最高(39.67%,48/121)。结论:早期筛查、控制HPV感染是降低宫颈癌发病率的有效途径。

Objective：To investigate HPV infection status of women in Chongqing in order to provide theoretical basis for the prevention and treatment of the cervical cancer.Methods：The infection status of HPV in 2 497 outpatients of gynecology department was examined with gene chip technique in Chongqing Obstetric and Gynecology Hospital from May 2009 to November 2011.The infection status of various subtypes of HPV was compared and analyzed.Results：Among the 2 497 patients,432 patients were infected with HPV（17.30%）,and 274 patients were infected with HR-HPV（high risk HPV,10.97%）.Out of the 23 subtypes of HPV,HPV-16（32.18%,139/432）was the most common of all types,followed by subtypes HPV-43（18.75%,81/432）,HPV-58（15.05%,65/432）,HPV-52（13.19%,57/432）,HPV-6（8.56%,37/432）,and there was no HPV-44 or HPV-MM4.In the HPV positive patients,103（23.84%,103/432） patients were compound infected,of whom 82（18.98%,82/432）patients were superinfected.The HPV positive rate in old women（≥50） was higher than that in the young crowd.Conclusion：It is important to detect and control HPV infection in order to prevent and treat cervical cancer.