摘要
高危神经母细胞瘤的治疗十分棘手。该文主要介绍儿童肿瘤研究组(COG)最新治疗方案,包括6个疗程的诱导治疗,期间进行外周血造血干细胞采集及手术切除,然后进行自体外周血造血干细胞移植;预处理方案采用马利兰加马法兰,术后行局部放疗和13-顺式维甲酸治疗。同时还介绍了目前国外处于临床研究阶段的部分治疗方法。[临床儿科杂志,2012,30(5):401-403]
So far the treatment of high-risk neuroblastoma is still very difficult;we hereby introduce the latest protocol from the Children＇s Oncology Group（COG）.It consists of 6 courses of induction chemotherapy,during which peripheral blood stem cells are harvested and tumor mass is removed,then followed by autologous peripheral blood stem cell transplantation.Busulphan and Melphalan are employed as conditioning regimen.Local radiation and maintenance therapy with 13-cis retinoid acid are proceeded as the last steps.In addition,some of new treatment protocols abroad that remain to be investigated are also introduced.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2012年第5期401-403,共3页
Journal of Clinical Pediatrics
关键词
神经母细胞瘤
高危
化疗
预处理
neurobalstoma
high risk
chemotherapy
conditioning regimen
