炎症递质与肥胖儿童糖脂异常代谢指标的关系研究

Inflammatory mediators on parameters for abnormal glucose and lipid metabolism in obese children

目的探讨肥胖儿童血糖、血脂异常及其与炎症递质变化的关系。方法选择儿科门诊就诊的符合单纯性肥胖诊断标准的肥胖儿童,以及年龄、性别相匹配的正常体质量健康儿童为研究对象,测定两组儿童的血清超敏C反应蛋白(CRP)、血清肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8),以及血糖、血脂、胰岛素水平等。结果 65例肥胖儿童与30例正常体质量儿童相比,CRP、TNF-α、IL-8水平明显增高,差异均有统计学意义(P<0.01)。肥胖儿童中,血糖、胰岛素、以及血胆固醇、三酰甘油、血高密度脂蛋白胆固醇水平异常者与正常者比较,其CRP、TNF-α、IL-8水平也均明显增高,差异有统计学意义(P<0.01)。结论肥胖儿童体内存在炎症反应状态。血糖、胰岛素、血脂升高可能肥胖与所致的炎症反应相关。[临床儿科杂志,2012,30(5):435-437]

Objective To investigate the relationship among blood glucose,blood lipid and inflammatory mediators in obese children.Methods Outpatients diagnosed with childhood simple obesity and healthy children with matched gender and age were enrolled.Serum supersensitive C reactive protein（CRP）,serum tumor necrosis factor-α（TNF-α）,interleukin-8（IL-8）,blood glucose,blood lipid,insulin were measured in both groups.Results Sixtyfive obese children compared with 30 healthy children,levels of CRP,TNF-α and IL-8 were significantly higher（P 0.01）.Among obese children,the levels of CRP,TNF-α and IL-8 were also significantly higher in children with abnormal blood glucose,insulin,cholesterol,triglyceride and high density lipoprotein（P 0.01）.Conclusions Inflammatory reaction status was observed in obese children,and it may relate to the increasing levels of blood glucose,insulin and blood lipid.