神经营养因子与神经干细胞的增殖与分化:基于汤森路透Web of Science数据库文献检索

Neurotrophic factors participate in proliferation and differentiation of neural stem cells:literature retrieval results based on Web of Science

背景:神经营养因子与神经干细胞的增殖、分化密切相关,在神经干细胞的诱导分化中起重要作用。目的:通过对汤森路透Web of Science数据库收录2002/2011有关神经营养因子与神经干细胞增殖分化作用相关文献的计量学分析,得出神经营养因子与神经干细胞增殖分化影响的国际动态研究的趋势。设计:文献计量学分析。资料提取:由第一作者检索汤森路透Web of Science数据库有关神经营养因子与神经干细胞增殖分化的文献,分析其研究进展。检索文献时间范围为2002-01/2011-12。入选标准:纳入标准:经同行评议的神经营养因子与神经干细胞增殖分化研究的已发表文章,包括研究原著,综述,会议记录,会议摘要。排除标准:①需采用手工检索和电话检索方式收集的文章。②未正式出版的文章。③在收录数量之外排除勘误类文献类型。主要数据的判断指标:①文献收录总量。②文献类型。③学科类型。④国家分布。⑤发文单位。⑥来源期刊。⑦高被引文章。结果:①汤森路透Web of Science数据库过去10年共收录神经营养因子与神经干细胞增殖分化研究相关文献257篇,其中神经生长因子与神经干细胞增殖分化研究相关的文献88篇,脑源性神经营养因子与神经干细胞增殖分化研究相关文献127篇,神经营养素3与神经干细胞增殖分化研究相关文献42篇。2002年仅发表并收录神经营养因子与神经干细胞增殖分化相关研究7篇,从2007年开始文献数量成倍增长,2010年收录该领域的相关文献达到顶峰,为43篇。其中研究类文章共收录225篇,综述类文章30篇。研究文字的学科领域集中在神经科学和细胞生物学方向。②目前已发表的文献美国为主,占全球相关领域发稿量的36.12%。中国在过去10年间被收录文章总量中位居第2名,共发表60篇相关文章,占全球相关文章的23.34%。其高被引文章主要发表在Cell Transplantation《细胞移植》、Journal of Neuroscience Research《神经科学研究杂志》、Neuroscience Letters《神经科学快报》和Brain Research《脑研究》杂志。结论:文献分析显示,近几年来神经营养因子与神经干细胞增殖分化研究趋于成熟,发文量稳定并且呈逐渐上升趋势,是目前该领域研究的热点。

BACKGROUND：Neurotrophic factors have a close relationship with proliferation and differentiation of neural stem cells and play an important role in induced differentiation of neural stem cells.OBJECTIVE：To identify the global research trends of effects of neurotrophic factors on proliferation and differentiation of neural stem cells via a bibliometric analysis of Web of Science.DESIGN：A bibliometric study.DATA RETRIEVAL：We performed a bibliometric analysis for data retrievals regarding effects of neurotrophic factors on proliferation and differentiation of neural stem cells from 2002 to 2011 via Web of Science.SELECTION CRITERIA：Inclusive criteria：Peer-reviewed articles about effects of neurotrophic factors on proliferation and differentiation of neural stem cells which were published and indexed in Web of Science,including articles of original research articles,reviews,meeting abstracts and proceeding paper.Exclusive criteria：articles need to be manually searched or accessed only through telephone;unpublished articles;correction paper.MAIN OUTCOME MEASUREMENTS：Total article outputs;type of articles;distribution of output in subject categories;publication distribution of countries;publication distribution of institutions;top cited paper;distribution of publications.RESULTS：From 2002 to 2011,257 papers studying effects of neurotrophic factors on proliferation and differentiation of neural stem cells were indexed in Web of Science,including 88 papers addressing nerve growth factor on proliferation and differentiation of neural stem cells,127 papers addressing brain-derived neurotrophic factor on proliferation and differentiation of neural stem cells,and 42 papers addressing neurotrophin 3 on proliferation and differentiation of neural stem cells.There were only 7 articles published in 2002,whereas the number of publications doubled since 2007.Totally 43 articles addressing neurotrophic factors on proliferation and differentiation of neural stem cells were published and covered in 2010,which reach a peak.Original research was the most frequently document type of published papers,which 225 original research paper were indexed and published in the past 10 years.The result showed that nearly one third of the literatures in the field were published by Americans institutes/universities.China was ranked No.2 in terms of number of literature published.It is interesting that most cited articles were mostly published in Cell Transplantation,Journal of Neuroscience Research,Neuroscience Letters and Brain Research.CONCLUSION：From the analysis of literature and research trends,we found that the research of effects of neurotrophic factors on proliferation and differentiation of neural stem cells is becoming more mature,and the number of literatures in this field is increasing.It is the research hot in recent years.