脐血间充质干细胞移植与免疫调节

Immunoregulation and human umbilical cord blood-derived mesenchymal stem cells transplantation

背景:近年研究显示,脐血间充质干细胞的自我更新和多向分化潜能为细胞移植治疗提供了基础条件,而其免疫调节功能也极大地拓展了细胞治疗的方向和范围。目的:就近期脐血间充质干细胞的免疫调节和细胞移植研究进行回顾分析。方法:应用计算机以"umbilical cord blood-derived mesenchymal stem cells"为关键词检索Pubmed数据库,以"脐血间充质干细胞"为关键词检索知网数据库,时间限定为2008-01/2011-06,语言种类为"English"和汉语。通过阅读标题和摘要进行初筛,排除研究内容与此文无关的文献、重复性研究及Meta分析,选择近期发表或发表在权威杂志的30篇文献进行综述。结果与结论:脐血间充质干细胞具有与骨髓间充质干细胞相似的自我更新和多向分化潜能。通过细胞移植技术,脐血间充质干细胞在糖尿病、神经退化性疾病如阿尔茨海默病和帕金森病等以及神经损伤后的修复治疗方面显示出很强的潜力。同时,脐血间充质干细胞又具有免疫调节作用,其可通过下调T细胞的增殖,降低免疫反应。利用该特点,脐血间充质干细胞在一些免疫性疾病,如移植物抗宿主病和狼疮性肾炎等疾病的细胞治疗方面也取得了积极的进展。

BACKGROUND：Research in recent years suggests that the self-renewal and multi-directional differentiation potency of human umbilical cord blood derived mesenchymal stem cells（UCB-MSCs） offer basic condition to cell transplantation treatment.Moreover,their immunoloregulation function enormously expands the direction and limits cell transplantation treatment.OBJECTIVE：To retrospectively analyze the immunoloregulation and human UCB-MSCs transplantation.METHODS：The key word ＂umbilical cord blood-derived mesenchymal stem cells＂ was used to search in Pubmed database and CNKI database from January 2008 to June 2011 in English and Chinese using computer.The preliminary screening was made through reading the title and abstract.The articles with unrelated contents,repetitive and Meta analysis were excluded.30 papers of pertinent literature to be published in the near future or published in the authority magazine were selected to review.RESULTS AND CONCLUSION：Human UCB-MSCs have the similar self-renewal and multi-directional differentiation potency with the bone marrow derived mesenchymal stem cells.Through cell transplantation technique,human UCB-MSCs show powerful potentiality in diabetes mellitus treatment,neural degeneration disease like Alzheimer＇s disease and Parkinson＇s disease and injury of nerve retreatment.Meanwhile,human UCB-MSCs have immunoregulatory ettects,they can lower immune reaction through down regulation of T-cells.We also get some advancements on several immunological diseases such as cell therapy of graft versus host disease and lupus nephritis.