即刻种植中异体脱细胞真皮基质引导的骨组织再生

Bone regeneration induced by allogeneic acellular dermal matrix during immediate implantation

背景:脱细胞真皮基质可作为软组织支架使成纤维细胞和上皮细胞在其中增殖,并最终成为宿主组织的一部分。目的:观察异体脱细胞真皮基质引导即刻植入种植体周围骨组织再生的效果。方法:选择口腔修复行即刻种植患者15例,使用异体脱细胞真皮基质行骨组织引导再生,种植体植入后,测量术中、植入后6,12个月唇侧骨壁厚度,同时观察种植体周围软组织愈合情况。结果与结论:6个月后均完成最终修复,无感染及明显并发症。异体脱细胞真皮基质有效关闭了即刻种植位点的软组织创口,6个月内逐渐与种植体周软组织发生整合。植入后6,12个月种植位点唇侧骨壁厚度与唇侧骨量高于术中测量值(P<0.05),植入后6,12个月组间骨壁厚度及骨量变化不明显(P>0.05)。说明异体脱细胞真皮基质作为屏障膜能有效引导骨组织再生,降低即刻种植术中关闭创口的难度,短期临床结果满意。

BACKGROUND： Acellular dermal matrix can be used as a type of soft tissue scaffold for the proliferation of fibroblasts and epithelial cells, and finally the matrix will become part of the host tissue. OBJECTIVE： To observe the bone regeneration induced by allogeneic acellular dermal matrix during immediate implantation. METHODS： Fifteen patients received immediate implantation were included in this study. Allogeneic acellular dermal matrix was used for bone regeneration. Clinical measurements describing the thickness of the buccal bone walls were recorded during implantation, after 6 months of operation and after 12 months of operation. Moreover, healing of the soft tissues around the implants was observed. RESULTS AND CONCLUSION： All patients received final restoration without infection or complications at 6 months after operation. The acellular dermal matrix effectively closed the immediate implant wound and was gradually incorporated with the soft tissues around the implants. The thicknesses and bone masses of the buccal bone wall at 6 and 12 months were obviously increased compared with those during operation （P〈0.05）, while those at 6 months and at 12 months were not different （P〉0.05）. It is indicated that allogeneic acellular dermal matrix used as barrier membrane can efficiently induce the bone regeneration, reduce the difficult of closing wound in immediate implantation and achieve a good short-time effect.