纤维蛋白胶在骨科中的应用

Application of fibrin glue in orthopedics

背景:纤维蛋白胶是一种生物蛋白制剂,由纤维蛋白原、凝血酶及其他生物活性因子组成,具有止血、趋化及促细胞有丝分裂等特性,有着良好的生物相容性。目的:对纤维蛋白胶在骨科的应用进行综述。方法:以"fibringlue,biomaterial,application"为英文检索词,以"纤维蛋白胶,骨科,应用"为中文检索词,检索PubMed、BP、SD、万方及维普等数据库1995-01/2011-05相关文献,选取纤维蛋白胶在骨科中的应用有关文献30篇进行总结。结果与结论:纤维蛋白胶是一种具有多向生物活性的生物蛋白,能迅速形成立体网状结构,起到良好的止血作用。在注射部位局部形成凝胶圈,起封闭与粘合作用。具有预防脊柱手术后硬脊膜外腔粘连,抑制局部炎症扩散,减轻水肿压迫,促进术后切口愈合的作用。能充当生物基质,应用于骨或软骨组织工程。

BACKGROUND： Fibrin glue （FG） is a fibrin preparation, which is composed by fibrinogen, thrombin and other biological activity, and it has various functions such as hemostasia, chemotaxis, promoting cell mitosis and other features, besides, it also has good biocompatibility. OBJECTIVE： To review the application of FG in orthopedics. METHODS： The PubMed, Biosis Preview, ScienceDirect, Wanfang and VIP databases were searched by using the keywords of ＂fibrin glue, biomaterial, application＂ in English and ＂fibrin glue, orthopedics, application＂ in Chinese for relevant articles addressing application of FG in orthopedics published 1995-01/2011-05. Finally, 30 articles were summarized. RESULTS AND CONCLUSION： FG is a kind of multi-bioactive fibrin, which can rapidly form three-dimensional network structure and play a good hemostatic effect. FG can form a local loop at the injection site to play a closed and adhesive effect, and it can be used for preventing postoperative epidural adhesions, inhibiting local inflammation, reducing swelling pressure, and promoting postoperative wound healing. FG can act as a biological matrix used in bone or cartilage tissue engineering.