肿瘤坏死因子α及C反应蛋白在老年哮喘患者中的意义

The Significance of TNF-α and C-reactive Protein in Asthma Disease

目的探讨老年哮喘患者血浆C反应蛋白(CRP)及血清肿瘤坏死因子α(TNF-α)的变化及临床意义。方法选取老年哮喘患者急性加重期、治疗后稳定期患者各18例及健康体查者16例,采用Elisa法及透射比浊法分别测定血清中TNF-α及CRP,并采用统计学方法比较三组之间的差异。结果老年哮喘急性加重期TNF-α水平为(32.40±8.10)pg/mL,稳定期为(13.12±5.90)pg/mL,急性加重期较稳定期明显增高(P<0.01)。正常对照组TNF-α水平为(7.81±2.23)pg/mL,与稳定期比较也有显著性差异(P<0.05)。老年哮喘急性加重期CRP水平为(73.2±13.74)mg/L,稳定期为(21.56±7.41)mg/L,急性加重期较稳定期明显增高(P<0.01)。正常对照组CRP水平为(4.35±1.92)mg/L,与稳定期比较也有显著性差异(P<0.05)。急性加重期TNF-α与CRP之间有相关性(r=0.635,P<0.05)。稳定期TNF-α与CRP之间有相关性(r=0.412,P<0.05)。结论 CRP与TNF-α参与老年哮喘的急性炎症过程。

Objective It is to investigate the clinical significance of serum tumor of factor-α and C-reactive protein in patients with ederly asthma diseases.Methos The serum samples were obtained from patients with ederly asthma during both acute exacerbation stage（18 cases each） and stable stage and health volunteers as controls（16 subjects）.The concentration of TNF-α in serum were detected by Elisa method and CRP by nephelcmetry method.Result The level of TNF-α in patients with asthma during acute exacerbationwas significantly higher than that during stable stage（P0.01）.The level of TNF-α in patients between asthma during stable stage and control group also had significant difference（P0.05）.The level of CRP during acute exacerbation stage was significantly higher compared with stable stage（P0.01）.The level of TNF-α had direct positive correction with CRP during acute exacerbation stage（r=0.635,P0.05）;The level of TNF-α had direct positive correction with CRP during stable stage（r=0.412,P0.05）.Conclusion TNF-α and CRP may be involved in the acute inflammation in asthma.