妊娠4～9周孕妇血清雌二醇变化与妊娠结局的关系

The relationship between serum estradiol level at pregnancy of 4 to 9 weeks and the pregnancy ending

目的探讨妊娠4～9周孕妇血清雌二醇(E2)变化与妊娠结局的关系。方法选择在本院就诊的妊娠4～9周的孕妇,根据孕妇妊娠结局分为正常妊娠组和胚胎停育组,正常妊娠组又根据有无复发性流产病史者分为两组,各组按孕周又分为6个亚组。采用化学发光分析法检测各组孕妇血清E2水平,并进行比较分析。结果正常妊娠组妊娠4～9周孕妇每周血清E2水平随妊娠周数增加而增加,有复发性流产病史的患者和无复发性流产的患者各孕周E2水平的变化差异无统计学意义(P>0.05);而胚胎停育组随孕周增加呈下降趋势。与正常妊娠组的相应孕周两两比较胚胎停育组各个孕周孕妇血清E2水平相应均数显著偏低(P<0.05)。结论胚胎停育孕妇各孕周血清E2水平均显著下降,提示E2可能是维持早期妊娠的重要因素之一。

Objective To explore the relationship between serum estradiol level at pregnancy of 4 to 9 weeks and the pregnancy ending. Methods The pregnant women who had conceived from 4 to 9 weeks were previously divided into 2 groups：normal pregnancy and missed abortion. The normal pregnancy group was further divided into recurrent miscarriage and non-recurrent miscarriage,and then each group was divided into 6 subgroups based upon gestational age. Chemiluminescence reaction were used to determine the serum estradiol levels. Results With an increase of gestational age, the level of serum E2 in women with normal pregnancy significantly increased, while the serum E2 level in women with missed abortion was significantly lower than normal pregnancy at the same gestational age. Conclusion The serum level E2 is significantly decreased in women with missed abortion,suggesting that serum E2 should be an important factor in early pregnancy.