摘要
目的比较结核分枝杆菌γ-干扰素体外释放试验(TB-IGRA)与结核菌素皮肤试验(TST)在临床上用于检测MTB感染者的应用价值。方法 TB-IGRA与TST平行检测对147例菌培阳性肺结核患者,并分析年龄、性别和是否接种卡介苗对各自检测性能的影响。TST分别比较红肿硬块直径≥5mm(TST5)和≥15mm(TST15)者。结果 TB-IGRA和TST5的检出率分别为80.3%(118/147)和78.2%(115/147),均显著高于TST15的44.2%(65/147)。TB-IGRA在60岁以下年龄组的检出率显著高于60岁以上年龄组,TST15检出率随年龄变化趋势与TB-IGRA类似。是否接种卡介苗对TB-IGRA和TST15没有明显影响,而TST5在接种过卡介苗的患者中的阳性率显著高于未接种组。结论 TB-IGRA比TST有更高的检测灵敏度,可以作为判断结核分枝杆菌感染的手段之一。
The aim was to evaluate the clinical value on detecting Mycobacteriurn tuberculosis (MTB) of interferon-gam- ma release assay (TB-IGRA) comparing with tuberculin skin test (TST). Total of 147 cases of culture-positive tuberculosis pa- tients were parallelly detected with TB-IGRA and TST, and the influence on their performance of age, sex and BCG vaccination were analyzed. TST was evaluated with two different criteria, diameter of swelling lumps ≥ 5mm (TSTs) and ≥ 15mm (TSTla) respectively. Results indicated that the positive rates of TB-IGRA and TST5 were 80. 30% (118/147) and 78. 20% (115/147) respectively, and significantly higher than 44.2G of TST1s (65/147). The positive rate of TB-IGRA in patients be- low 60-year-old was significantly higher than those above 60-year-old, and that was observed in the results of TSTls. Vaccina- tion of BCG had no influence on the preformation of TB-IGRA and TST15, but the positive rate of TST5 was significantly higher in vaccinated group than in non-vaccinated group. In conclusion,TB-IGRA has higher sensitivity than TST, and could be used as one of the means to detect the MTB infection.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2012年第5期464-466,共3页
Chinese Journal of Zoonoses
基金
国家十一五科技重大专项资助项目(2008ZX10003-004)
福建省自然科学基金(2009-51)
厦科发计(2009-15)
厦卫科教中医(2009-627)联合资助
关键词
结核
皮肤试验
Γ-干扰素
体外释放试验
tuberculosis
tuberculin skin test
interferon-gammal in vitro release assay