口腔挥发性硫化物水平与牙周炎及舌苔的相关性研究

Correlation of volatile sulfide compounds in the oral cavity with periodontitJs and tongue coating

目的 研究口气中挥发性硫化物（VSC）与牙周临床指标及舌苔的相关性。方法 采用鼻闻法评定口臭值（OS），筛选出口臭值≥2，全身健康牙周炎患者50例。使用便携式气相色谱仪（Oral Chroma^TM）检测每例患者口气中硫化氢（H2S）、甲基硫醇（CH3SH）、二甲基硫[（CH3）2S]的浓度。记录牙周袋探诊深度（PD），出血指数（BI），菌斑指数（PLI）以及舌苔厚度（Tt）与舌苔面积（Ta）。结果 口臭值（3．28±0．75）与VSC中硫化氢、甲基硫醇、二甲基硫的水平[（810．30±204．09、234．53±113．88、21．45±13．12）μg／L]呈正相关（r=0．456、r=0．386、r=0．325，均P〈0．05）。与PLI、BI也呈正相关（r=0．528，r=0．558，均P〈0．05）。硫化氢与PD、BI间呈正相关（r=0．356，r=0．306，均P〈0．05）。甲基硫醇与PLI、PD、BI均呈正相关（r=0．416、r=0．407、r=0．489，均P〈0．05）。二甲基硫与PD、BI问均呈正相关（r=0．369，r=0．443，均P〈0．05）。口臭值、硫化氢与舌苔面积、舌苔厚度均呈正相关（P〈0．05）。甲基硫醇与舌苔厚度呈正相关（P〈0．05）。结论 口气挥发性硫化物中二甲基硫可能主要来源于牙周袋，而硫化氢和甲基硫醇则可能来源于牙周炎与舌苔。

Objective To examine the correlation among volatile sulfide compounds （VSC） in exhaled breaths with clinical periodontal index and tongue coating. Methods A total of 50 patients who was free of systemic disease but suffered from periodontitis with organoleptic score （OS） of ≥2 based on organoleptic rating were screened. The concentrations of hydrogen sulfide, methyl mercaptan and dimethyl sulfide in exhaled breaths were measured by using a portable sulfide monitor （Oral ChromaTM）. The periodontal probing depth （PD）, bleeding index （BI）, plaque index （PLI）, thickness of tongue coating （Tt） and area of tongue coating （Ta） were examined. Results OS （3.28±0.75） was positively correlated with concentrations of hydrogen sulfide, methyl mereaptan and dimethyl sulfide in VSC [ （810.30±204.09, 234.53± 113.88,21.45±13.12） μg/L, r=0.456, r=0.386, r=0.325, all P〈0.05 ]. There was a positive correlation between OS and PLI as well as between OS and BI （r=0.528 and 0.558, respectively, both P〈0.05）. Concentration of hydrogen sulfide was shown to be positively correlated with PD and BI （r=0.356 and 0.306, respectively, both P〈0.05）. Concentration of methyl mercaptan was positively correlated with PLI, PD and BD （r=0.416, 0.407 and 0.489, respectively, all P〈0.05）. And the concentration of dimethyl sulfide showed positive correlation with PDand BI （r=0.369 and 0.443, respectively, both P〈0.05）. In addition, both OS and concentration of hydrogen sulfide were revealed to be positively correlated with Ta and Tt （all P〈0.05）. By contrast, there was positive correlation between the concentration of methyl mercaptan and Tt （P〈0.05）.