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二苯乙烯衍生物的合成及抗肿瘤活性 被引量：4

Synthesis and antitumor activity of stilbene derivatives
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摘要 以甲氧基取代的4’-氨基二苯乙烯与4-溴甲基-5-甲基-1,3-二氧杂环戊烯-2-酮为原料,通过亲核取代反应合成得到了4种新的二苯乙烯衍生物。这些化合物的结构经NMR、IR和元素分析确定。以HeLa、SMMC-7721、BGC-823和A549为受试细胞株,用MTT法测试了这4种化合物的抗肿瘤活性。测试结果表明,这些化合物具有一定的抗肿瘤活性。 Four new stilbene derivatives were synthesized by nucleophilic substitution from substituted 4＇ -amino stilbene and 4-bro- momethyl-5-methyl-1,3-dioxolene-2-one. The structures of the compounds were characterized by elemental analysis, IR and NMR spectra. The antitumor activities of compounds were determined with MTT method. The results showed that they displayed a distinct cytotoxicity to HeLa,SMMC-7721 ,BGC-823 and A549 cells.
作者 顾红梅 张喜全 徐宏江 王丽 李宝林
机构地区 江苏正大天晴药业股份有限公司 教育部药用资源与天然药物化学重点实验室
出处 《化学研究与应用》 CAS CSCD 北大核心 2012年第5期773-777,共5页 Chemical Research and Application
关键词 二苯乙烯衍生物 抗肿瘤活性 合成 stilbene derivatives antitumor activity synthesis
分类号 O626 [理学—有机化学]
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参考文献10

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共引文献6

同被引文献40

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引证文献4

二级引证文献11

化学研究与应用
2012年 第5期

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