靶向治疗在复发性卵巢癌治疗中的应用

Targeted therapy for recurrent ovarian cancer

复发与耐药是卵巢癌治疗失败的主要原因之一。近20年来,手术、化疗及放疗的发展在改善复发性卵巢癌预后方面发挥的作用有限。靶向治疗以肿瘤细胞在分子水平的特征性改变为作用靶点,发挥抗肿瘤的作用。近10年来,有大量临床研究对靶向药物治疗复发性卵巢癌的疗效与副反应进行了评价,并取得了一定的成果。

Recurrence and drug-resistance are major causes of treatment failure in ovarian cancer. In the past 20 years, the development of operation, chemotherapy and radiotherapy play a limited role in impro- ving the prognosis of recurrent ovarian cancer. Targeted therapy has an antitumor activity by targeting specific molecular changes within tumors. In the recent decade, there were many clinical trials which evaluated the efficacy and safety of targeted therapy in recurrent ovarian cancer.