2型糖尿病大血管病变患者CRP、TNF-α、APN水平的检测及临床意义

Level of CRP,TNF-αand APN and their clinical significance in type 2 diabetes with macroangiopathy

目的:探讨2型糖尿病大血管病变患者C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、脂联素(APN)的水平及临床意义。方法:125例2型糖尿病患者分为两组,有大血管病变患者65例为A组,无大血管病变患者60例为B组,同时选取50例健康者作为对照组。检测并比较3组血清超敏C反应蛋白(hs-CRP)、TNF-α、APN水平及颈动脉内膜-中膜厚度(IMT)。结果:A组、B组及对照组血清hs-CRP、TNF-α水平及IMT依次降低,APN水平依次升高,组间比较差异均有统计学意义(F值分别为7.218、8.924、7.721、6.356,P均<0.05);Pearson相关分析显示:A组hs-CRP、TNF-α、APN水平与IMT显著相关(r值分别为0.357、0.287、-0.639,P均<0.05)。结论:hs-CRP、TNF-α及APN参与动脉粥样硬化的发生机制,与2型糖尿病大血管病变密切相关。

Objective： To explore the change of CRP, TNF-α and APN and their clinical significance in type 2 diabetes patients with macroangiopathy. Methods：A total of 65 cases of type 2 diabetes with macroangiopathy were selected as group A, 60 patients of type 2 diabetes without macroangiopathy as group B and 50 healthy persons as control group, hs-CRP, TNF-α, APN and IMT were measured and compared among three groups. Results： Hs-CRP, TNF-α and IMT were highest and APN was lowest in group A followed by group B and control group with significant difference （ F= 7. 218, 8. 924, 7. 721, 6. 356 ,P〈0. 05） ; Pearson correlation analysis showed that hs-CRP, TNF-α and APN level in diabetes patients were positively correlated with IMT （r = 0. 357,0. 287, - 0. 639, P〈 0.05）. Conclusions： Hs-CRP, TNF-α and APN participate in the pathogenesis of atherosclerosis, and have a close relationship with macroangiopathy in type 2 diabetes patients.