他汀类药物对冠心病支架术后患者脂蛋白(a)的影响研究

Effect of statins on lipoprotein(a) after stenting for coronary artery disease

目的:探讨他汀类药物对冠心病支架术后患者脂蛋白(a)(Lpa)的影响。方法:对我院收治的172例冠心病经皮冠状动脉支架术治疗患者在术前及术后给予阿托伐他汀进行治疗。结果:患者术后1年TG浓度较术前明显降低(P<0.05);患者术后1年Lpa水平较术前无明显变化(P>0.05);高水平Lpa患者其并发症(16/102)发生率明显高于低水平Lpa患者(3/70)(P<0.05);高水平Lpa患者随访不良结果发生率(19/102)高于低水平Lpa患者(3/70)(P<0.05)。结论:他汀类药物对冠心病支架术后患者Lpa无较大影响。Lpa水平与患者并发症以及不良结果的发生均有明显相关性。

Objective- To evaluate effect of statins on lipoprotein （a） after stenting for coronary ar- tery disease. Methods：A total of 172 coronary artery disease patients with percutaneous coronary stenting were selected, and were atorvastatin before and after surgery. Results-One year after treatment, TG was significantly decreased（P〈0.05）, and there was no significant difference in Lpa compared with that before surgery （P〉0.05）. The incidence of complication was significantly higher in patients with high Lpa （16/ 102 vs. 3/70） （P〈0.05）, and the incidence of side effect was also significantly higher in patients with high Lpa （19/102 vs. 3/70） （P〈0.05）. Conclusion. Statins have no significant effect on Lpa of coronary artery disease patients after stenting. Lpa level has remarkable correlation with the incidence of complication and adverse effect.