HDLF方案联合腹腔灌注化疗治疗晚期胃癌的疗效

Curative effect of HDLF combined with abdominal perfusion chemotherapy for advanced gastric cancer

目的:探讨羟基喜树碱(HCPT)、顺铂(DDP)、亚叶酸钙(CF)与氟尿嘧啶(5-Fu)静脉化疗联合DDP和5-FU腹腔灌注化疗治疗晚期胃癌的临床疗效和毒性反应。方法:采用生理盐水1 000mL+DDP 60mg+5-Fu 1.0g腹腔灌注化疗,联合HCPT 10mg,d1～5,CF 0.1g和5-Fu 0.5g静脉化疗治疗41例晚期胃癌患者。结果:41例患者总有效率(CR+PR)为58.5%。不良反应主要表现为消化道反应和骨髓抑制,且以1、2级为主。结论:HDLF方案联合腹腔灌注化疗治疗晚期胃癌的疗效较好,不良反应轻,安全有效,患者的化疗成功率高且生存质量改善,值得临床进一步研究。

Objective： To study the curative effects and toxicity of hydroxyl xi trees bases（HCPT）,cisplatin（DDP）,and folic acid calcium（CF） and fluorouracil（5 its） venous chemotherapy combined with DDP 5 abdominal perfusion chemotherapy for advanced gastric cancer.Methods： Physiological saline 1 000 mL ＋ DDP 60 mg ＋ 5 its 1.0 intraperitoneal chemotherapy combined with HCPT 10 mg,d1-5,CF 0.1 and 5 its 0.5 venous chemotherapy were used to treat 41 patients with advanced gastric cancer.Results：Total effective rate of the 41 patients（CR ＋ PR） was 58.5%.Toxic effects mainly are level Ⅰand Ⅱ gastrointestinal reaction and bone marrow inhibition.Conclusion： HDLF combined with DDP 5 abdominal perfusion shows good effects on gastric cancer with light side effects and great safety.It also improves patients＇ survival rate and life quality,thus it＇s worthy of further study.