早期乳腺癌保乳术后放疗89例临床疗效分析

Effect of radiotherapy after breast-conserving surgery on treatment of 89 patients with early breast cancer

目的:观察保乳术后放疗治疗早期乳腺癌的临床疗效。方法:将符合标准的152例早期乳腺癌患者随机分成观察组(89例)和对照组(63例),观察组采用保乳术后放疗治疗,对照组仅采用保乳手术治疗,评价其疗效差异。结果:治疗前两组的Karnofsky评分无显著差异(P>0.05),经保乳手术治疗后Karnofsky评分均显著上升,且观察组上升幅度明显强于对照组,差异有统计学意义(P<0.05);观察组医生和患者对美容效果的满意率为94.38%,明显高于对照组84.14%(P<0.05);观察组随访5年的局部复发率和远处转移率显著低于对照组,而无瘤生存率和总生存率显著高于对照组(P<0.05)。结论:乳腺癌保乳术后放疗具有疗效满意、放疗反应轻微,安全可靠等优点,值得临床推广。

Objective： To evaluate the clinical efficacy of radiotherapy after breast-conserving surgery in treatment of patients with early breast cancer.Methods：A total of 152 patients with early breast cancer were randomly divided into observation group（89 cases） and control group（63 cases）.Patients in control group received only conserving surgery,while patients in observation group received radiotherapy after breast-conserving surgery.The curative effect between two groups was observed and compared.Results：There was no significant difference in Karnofsky score between two groups before surgery（P0.05）.The score was significantly increased after breast-conserving surgery,and the increase was more significant in observation group（P0.05）.Satisfactory rate in observed group were significantly higher than those in the control group（94.38% vs.84.14%）（P0.05）.Five-year follow-up showed local recurrence and distant metastasis rate in observed group were significantly lower than those in the control group（P0.05）,while the 5-year overall survival rate in observed group were significantly higher than that in the control group（P0.05）.Conclusions： Radiotherapy after breast-conserving surgery is of satisfactory efficacy and few complications.It is safe and reliable,and is worthy to be popularized.