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肾上腺髓质素和其受体在肾细胞癌组织中的表达和意义 被引量：1

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摘要 目的探讨肾细胞癌(RCC)组织中肾上腺髓质素(ADM)和肾上腺髓质素受体(ADMR)的表达及意义。方法采用流式细胞学方法检测33例肾细胞癌组织及癌旁组织中ADM和ADMR的表达,并计数肾癌组织微血管密度(MVD),并分析其相关性。结果 ADM、ADMR及MVD在肾细胞癌组织中表达明显高于正常肾组织(P均<0.05);ADM、ADMR在肾细胞癌组织中表达具有相关性(r=0.929,P<0.05),ADM及ADMR表达与MVD具有明显相关性(r分别为0.969、0.946,P均<0.05)。结论肾上腺髓质素在肾肿瘤的发生和发展过程中起一定作用,可能参与肿瘤血管的生成。
作者 乔娜 王东彬 李中华 蔡文清 杨书文 黎玮 张勇 汪鑫 杨照宇
机构地区 河北医科大学第二医院
出处 《山东医药》 CAS 2012年第15期72-73,共2页 Shandong Medical Journal
关键词 肾细胞癌 肾上腺髓质素 肾上腺髓质素受体 微血管密度 流式细胞学
分类号 R737.1 [医药卫生—肿瘤]
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参考文献9

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二级参考文献14

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山东医药
2012年 第15期

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