水蛭胶囊对急性出血性中风患者血肿吸收速度和神经功能的影响

The influences of Shuizhi capsule(水蛭胶囊) on the absorbed velocity of the hematoma and nervous function with acute haemorrhagic apoplexy

目的 :观察水蛭胶囊治疗急性出血性中风的临床疗效及对患者血肿吸收速度及神经功能的影响。方法 :10 0例患者随机分为 2组 ,治疗组 (5 0例 )给予水蛭胶囊 0 .5 g口服 ,每日 3次 ;对照组 (5 0例 )口服脑复康片0 .8g,每日 3次 ;2组均治疗 5周。观察 2组患者治疗前后血肿吸收速度和神经功能缺损程度评分 ,同时检测高密度脂蛋白 (HDL)、低密度脂蛋白 (L DL)、总胆固醇 (TC)和甘油三酯 (TG)。结果 :治疗组治疗 5周平均血肿吸收量 (33.6± 2 .3) ml,对照组为 (2 7.5± 1.9) ml,2组比较差异显著 (P<0 .0 1) ;与对照组比较 ,治疗组 HDL显著升高 (P<0 .0 1) ,L DL 明显降低 (P<0 .0 5 ) ,TC、TG显著降低 (P均 <0 .0 1) ;治疗组治疗 5周后神经功能缺损评分 (17.2± 1.3)分 ,较对照组 (2 5 .5± 1.5 )分显著降低 (P<0 .0 1) ,临床总有效率 (92 % )明显高于对照组(72 % ,χ2 =7.9,P<0 .0 1)。结论 :水蛭胶囊能减少急性出血性中风患者的脑水肿 ,促进血肿吸收和神经功能的恢复 ,提高临床疗效 ,降低致残率。

Objective:To observe the curative effects of Shuizhi capsule(水蛭胶囊) on acute haemorrhage apoplexy and the effect on the absorbed velocity of the hematoma and nervous function.Methods:100 patients with acute haemorrhagic apoplexy were randomly divided into two groups.The treatment group ( n =50) was treated with Shuizhi capsule oral use,0 5 g three times daily.The control group ( n =50) was treated with Naofukang tablets(脑复康片) 0 8 g three times daily.Five weeks were one therapeutic course for both two groups.Before and after treatment,the damaged nervous function and the absorbed velocity of the hematoma were observed.Highdensity lipoprotein(HDL),lowdensity lipoprotein (LDL),total cholesterol(TC) and triglyceride(TG)were tested.Results:The mean absorbed quantity of the hematoma was (33 6±2 3)ml in treatment group,the control group was (27 5±1 9)ml,the difference between the two groups was significant ( P <0 01).By comparison with control group,HDL of the treatment group increased significantly ( P <0 01),LDL,TC and TG decreased significantly ( P <0 05 or P <0 01).After therapy in treatment group,the scores of nervous functional defects 〔(17 2±1 3)scores〕 were significantly lower than those 〔(25 5±1 5)scores〕 in control group( P <0 01),furthermore,the total effective rate in treatment group (92%) was significantly higher than that (72%) in control group (χ 2=7 9, P <0 01).Conclusions:Shuizhi capsule can alleviate the cerebral edema on acute haemorrhagic apoplexy,promote absorption of hematoma and recovery of neuronal function,increase the clinically curative effects and decrease disability rate.