摘要
目的 :以高效液相色谱外标法测定盐酸西替利嗪口服液含量。方法 :采用硅胶色谱柱 ( 5 μm ,15 0mm×6mm) ,乙腈 水 稀硫酸 ( 95∶4.7∶0 .3)为流动相 ,检测波长 2 30nm。结果 :该法能较好地分离被测组分和苯甲酸钠 ,被测组分线性关系良好 ,回收率满意。结论 :该法专属性好 ,快速 。
OBJECTIVE:To establish a HPLC method for determination of cetrilizine HCl in oral solution.METHODS:A column packed with silica gel(5μm,150mm×6mm);a mobile phase of acetonitrile∶H 2O∶dilute sulfuric acid=95∶4.7∶0.3;and a UV detector of 230 nm were adopted in this study.RESULTS:Cetrilizine HCl and sodium benzoate,a preservative in the oral solution,can be well separated by the method with a satisfactory linear range and recoveries.CONCLUSION:A rapid,accurate,and specific method for determination of citrilizine in oral solution was established.
出处
《中国新药杂志》
CAS
CSCD
2000年第5期318-319,共2页
Chinese Journal of New Drugs