机械通气联合雾化吸入治疗COPD呼吸衰竭疗效观察

Observation of the Efficacy of mechanical ventilation combined with aerosolization inhalation to treat respiratory failure in patients with chronic obstructive pulmonary disease

目的双水平无创正压通气(BiPAP)联合药物雾化吸入治疗AECOPDⅡ型呼吸衰竭疗效观察。方法 52例AE-COPDⅡ型呼吸衰竭患者在常规治疗基础上随机分为A、B两组,A组BiPAP治疗。B组BiPAP联合药物雾化吸入治疗,观察两组临床情况变化及机械通气时间、住ICU天数。结果治疗后B组血气指标、氧合指数、呼吸频率较A组改善明显(P<0.05),B组机械通气时间、住ICU天数少于A组。结论 BiPAP联合药物雾化吸入治疗AECOPDⅡ型呼吸衰竭疗效好。

Objective Observation of the efficacy of bi-level positive airway pressure ventilation（BiPAP） combined with drug aerosolization inhalation to treat respiratory failure in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 52 patients were randomly divided into group A and group B with based on routine therapies.group A received BiPAP treatment.Group B were received BiPAP combined drug aerosolization inhalation treatment.Changes of clinical situation,time of mechanical ventilation and days of hospitalization in ICU were observed.Results Arterial blood gas（PaO2、PaCO2）、PaO2/FiO2 and respiratory rate of group B had significant improvement over group A after treatment（P0.05）.Time of mechanical ventilation and days of hospitalization in ICU of group B were also fewer than group A.Conclusion BiPAP combined with drug aerosolization inhalation to treat respiratory failure in AECOPD is more effective.