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Morris水迷宫训练后即早基因c-Fos及c-Jun在大鼠丘脑前核的表达 被引量：4

Expression of c-Fos and c-Jun genes in the anterior thalamus nucleus of Morris water maze rats
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摘要 目的为探讨Morris水迷宫训练后丘脑前核内c-Fos和c-Jun的表达。方法 30只成年大鼠均分为正常组,假训练组和Morris水迷宫训练组,通过免疫组化和WesternBlot检测c-Fos和c-Jun的表达。结果 Morris水迷宫训练组丘脑前核c-Fos表达水平与假训练组和正常组比较明显增强(P<0.05),丘脑前背侧核显著强于前腹侧核(P<0.05)。训练组c-Jun表达水平与假训练组和正常组比较明显增强(P<0.05)。结论 c-Fos和c-Jun可能参与空间学习记忆过程。 Objective To explore the expression of immediately early genes of c-fos and c-jun in the anterior thalamus nucleus of Morris water maze rats.Methods 30 rats were divided into normal control,sham and Morris water maze groups averagely,the expression of c-Fos and c-Jun was detected in anterior thalamus nucleus by means of immunohistochemistry and Western blot.Results After Morris water maze training,AD was significantly enhanced compared to AV（0.05）.The expression levels of c-Fos and c-Jun proteins in the anterior thalamus nucleus（ATN） were higher in Morris water maze training group than in sham and normal control groups（0.05）,and higher in anterior dorsal nucleus than in anterior ventral nucleus.Conclusion c-fos and c-jun genes might be related to the process of learning and memory.
作者 何绘敏 王滨 马晓凯 孙谨 岳晓玲 肖绪武
机构地区 大连市妇幼保健院 大连医科大学解剖学教研室
出处 《解剖科学进展》 CAS 2012年第3期255-258,264,共5页 Progress of Anatomical Sciences
基金 国家自然科学基金资助项目(No.30470551 30270442)
关键词 丘脑前核 MORRIS水迷宫 即早基因 大鼠 anterior thalamic nucleus Morris water maze c-fos c-jun rat
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献15

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同被引文献45

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解剖科学进展
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