Frat1过表达与非小细胞肺癌的不良预后相关

Correlations of Frat1 with poor prognosis of non-small cell lung cancer

目的 Frat1蛋白在食管癌、卵巢癌、中枢神经系统肿瘤中有异常表达,但是在非小细胞肺癌(NSCLC)组织中的表达情况研究甚少,其表达情况与患者预后之间是否存在相关性等尚不清楚。方法用免疫组化SP法对100例原发性NSCLC患者手术标本中Frat1的表达进行检测。结果 Frat1蛋白在肺癌组织中的表达明显增强,Frat1的阳性表达与分化程度(P=0.022)、淋巴结转移(P=0.016)和TNM分期正相关(P=0.011),并且Frat1阳性表达患者的术后生存时间(41.651±4.445个月)明显低于阴性者(74.222±6.844个月,P=0.035)。结论 Frat1在NSCLC中过表达,与肺癌的侵袭和转移等恶性表型有关,Frat1的异常表达提示NSCLC患者的不良预后。

Objective As a positive regulator of the Wnt signal pathway,frequently rearranged in advanced T-cell lymphomas（Frat1） overexpressed in some human tumors,but the role of Frat1 in non-small cell lung cancer（NSCLC） is not clear,the purpose of this study is to investigate the expression and correlations of Frat1 with clinic-pathologic parameters and prognosis in lung cancer.Method Immunohistochemistry was performed on 100 cases of NSCLC with complete follow-up records.The correlations between expressions of Frat1 and clinic-pathological characteristics and prognosis were analyzed.Results Frat1 was not detected in normal bronchial and alveolar epithelium,while it was positively expressed in 63（63.00%） of 100 NSCLC cases.The expression level of Frat1 was positively related to tumor differentiation,TNM stage and lymph node metastasis（0.05）.The Kaplan-Meier survival analysis showed that survival time was significantly shorter in Frat1 positive expression cases than in Frat1 negative expression cases（0.01）.Conclusion Overexpression of Frat1 in NSCLC is associated with malignant phenotype and poor prognosis,down-regulation of Frat1 expression can restrain the invasive ability of lung cancer cells.