水合氯醛不同时间给药对行肺功能检查患儿催眠作用的影响

Influence of different time of chloral hydrate delivery on the hypnosis of children with pulmonary function test

目的观察肺功能检查前10％的水合氯醛不同时间点给药方法对不同年龄患儿的催眠效果，讨论其临床疗效。方法选取200例哮喘、喘息性支气管炎需做肺功能检查的患儿随机分为实验组和对照组各100例，实验组选择患儿入睡前10～30min应用水合氯醛进行催眠，对照组选择按常规执行医嘱时间或按预约的时间应用水合氯醛，比较两组患儿用药后入睡的时间、程度，是否完成肺功能检查。结果实验组应用水合氯醛后有效率为98％高于对照组的70％，差异有统计学意义（Z=6．1389，P〈0．01）；不同年龄阶段的患儿应用水合氯醛灌肠后入睡时间及镇静效果实验组均优于对照组，差异均有统计学意义（Z分别为3．1752，3．9635，2．8501，4．8888；P〈0．01）。结论小儿肺功能检查应用水合氯醛灌肠催眠应根据睡眠周期进行个体化给药才能取得较好的效果。

Objective To study the effect of the 10% of chloral hydrate delivery in different time on the children before they receive the pulmonary function test so as to discuss clinical effects. Methods Totals of two hundred children with asthma or asthmatic bronchitis needed the pulmonary function test were recruited, and randomly divided into experience group and control group with each group one hundred cases. Experience group received the chloral hydrate to hypnosis in ten to thirty minutes before they fall asleep, while control group received in doctor＇ s advice or appointment time. Then, the time of falling asleep, sleep level, the situation of test finishing in two group were observed and compared. Results The effective rate of chloral hydrate in experience group was 98% which was significantly higher than 70% in control group（P 〈 0. 01 ）and there was significant difference between two groups in the time of falling asleep and the sedation effect among the different ages （P 〈0. 01 ）. Conclusions Personal medicine delivery can get the better effect, which is chloral hydrate delivery according to the sleep cycles of children before they receive the pulmonary function test.