大蒜抑制实验性前胃鳞癌及癌前病变的研究

Inhibitory Effect of Garlic on Experimental Squamous Cell Carcinoma and Precancerous Lesion in Forestomach of Rats

目的 观察大蒜对甲基硝基亚硝基胍 (MNNG)诱发大鼠前胃鳞癌及癌前病变的影响。方法 MNNG组、预防组、治疗组分别给予MNNG(每天 5ml,含MNNG 1.2 5mg)诱发大鼠前胃鳞癌及癌前病变 ,预防组另给 10 %大蒜匀浆 10ml/d ,10个月后停药。预防组与治疗组继续给大蒜匀浆 ,至 16个月。结果 MNNG组、预防组、治疗组分别诱发大鼠不典型增生 2 4只 (96 .0 % )、16只 (53.3% )和 9只 (4 5.0 % ) ,癌变 15只 (6 0 .0 % )、7只 (2 3.3% )和 4只 (2 0 .0 % )。经统计学处理 ,加用大蒜的预防组、治疗组与MNNG组均有显著性差异(P <0 .0 5)。结论 表明大蒜对MNNG诱发大鼠前胃鳞癌及癌前病变有抑制作用。

Objective: To investigate the effects of garlic on squamous cell carcinoma (SCC)and precancerous lesion in forestomach of Wistar rats induced by N-methy-N-nitro-N-nitrosoguanidine(MNNG).Methods:Forestomach carcinoma and precancerous lesion were induced by 5 ml (including 1.25 mg MNNG) per day for 10 months in MNNG group(30 rats),prevention group(30 rats) and treatment group(20 rats)while 10% garlic juice (GJ)10 ml per day was given to prevention group.After 10 months,10% GJ 10 ml per day were given to the experimental group,and running water to control group.Results:In MNNG group,prevention group and treatment group,24(96.0%),16(53.3%) and 9(45.0%) case a typical hyperplasia were induced respecrively;15(60.0%),7(23.3%)and 4(20.0%)SCC were induced ,respectively.The difference between prevention group and treatment group with MNNG group was significant (P<0.05).Conclusions:garlic for experimental squamous cell carcinoma and precancerous lesion in forestomach has inhibitory effect.