摘要
Ménétrier's病(Ménétrier'sdisease,MD)是一种罕见的肥厚性胃炎,以胃黏膜皱襞粗大、肥厚致大量蛋白质丢失,黏液分泌增加,胃酸分泌减少及低蛋白血症为特征.本文报道MD致顽固性低蛋白血症1例.患者,女,55岁,以"食欲减退,颜面及双下肢水肿半年"入院.其血清总蛋白39.8g/L,白蛋白23.8g/L.CT示胃黏膜皱襞弥漫性、不均匀增厚.胃镜示胃底和胃体黏膜皱襞肥厚、粗大,胃内见大量黏液潴留病理示胃小凹显著变长,呈螺旋状改变,固有层内腺体增生,部分腺体呈囊性扩张,可见黏液积聚.本病例提示,对于无任何胃病症状而出现无法解释的顽固性低蛋白血症患者,及时采取CT和内镜检查有助于早期诊断.
Ménétrier＇s disease（MD） is a rare hypertrophic gastropathy characterized by giant,hyperplastic gastric mucosal folds,hyperproliferative protein-losing gastropathy,hypoalbuminemia,increased mucus secretion,and hypochlorhydria.Here we report a case of MD with refractory hypoalbuminemia in a 55-year-old female patient who presented to our hospital with anorexia,edema in the face and double lower limbs for half a year.Her serum total protein level was 39.8 g/L and her albumin level was 23.8 g/L.A CT scan revealed diffuse,uneven thickening of large gastric mucosal folds.Gastroendoscopy showed hyperplastic gastric mucosal folds in the body and fundus and profuse mucus.Micro,scopic examination of the biopsied specimens showed massive hyperplasia of surface and glandular mucous cells,a remarkable distortion of the foveolar,tortuosity and cystic dilatation of the glands.CT and endoscopy can help arrive at an accurate diagnosis of unexplained refractory hypoalbuminemia in patients without any gastropathy symptoms.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第13期1160-1163,共4页
World Chinese Journal of Digestology
