不同程度阻塞性睡眠呼吸暂停合并高血压与血管紧张素转换酶基因I/D多态性的比较研究

Comparison of ACE Gene Insertion/Deletion(I/D) Polymorphism in Patients with Different Degree of Obstructive Sleep Apnea and Hypertension

目的 :评价阻塞性睡眠呼吸暂停 (OSA)合并高血压(HT)与血管紧张素转换酶 (ACE)基因多态性的关系。方法 :采用病例对照研究方法 ,以 OSA的严重程度将研究对象分为正常对照组 (6 8人 )、HT组 (45人 )、轻度 OSA合并 HT组 (2 7人 )、中重度 OSA合并 HT组 (31人 ) ,共 171例 ;(2 )观察 ACE I/ D多态在一个 OSA典型家系中的分布。结果 :(1) ACE I/ D等位基因的频率分布如下 :中重度 OSA合并 HT组 ,I等位基因的频率显著高于其他各组 (P<0 .0 0 1) ;而正常对照组、HT组和轻度 OSA合并 HT组之间 I等位基因频率分布没有显著性差别 ;(2 )在一个典型 OSA家系中 I等位基因呈高频率出现。结论 :ACE基因 I等位基因与中重度 OSA显著相关 ,遗传因素是影响中重度 OSA合并

Objective:To compare the polymorphism of angiotensin convert enzyme(ACE) gene insertion/deletion(I/D) in the patients with different degree ofobstructive sleep apnea(OSA). Methods:Case control design.(1)The subjects were divided into four groups depending on the severity of the OSA, normal control group( n =68), HT group( n =45), HT with mild OSA group( n =27), HT with moderate and severe OSA group( n =31),174 subjects in total;(2)Analyzing distribution of ACE gene I/D allele and genotypes in a OSA family. Results: We found that the frequency of ACE gene I/D allele and genotypes were different in the four groups( P <0 001). The frequency of I allele and II genotype is significantly higher in the HT with moderate and severe OSA group than that of the other groups( P <0 001). There were no significant differences of the distribution of I allele and II genotype among the control group, the HT group and HT with mild OSA group;(3)The higher frequency of I allele and II genotype was observed in the OSA family also. Conclusion:The frequency of ACE gene I allele and II genotype were significantly related to HT with OSA patients, and inherited factors may played an important role in the etiology of OSA.