临界高血压患者淋巴细胞β受体密度与β阻断剂治疗变化的研究

Density of β-adrenorecptor in Lymphocte and its Changes after the β-adrenorecptor Antagonist Treatment in Borderlines Hypertensives

目的 :探讨临界高血压患者淋巴细胞β受体密度与β阻断剂治疗变化方法 :采用 Ficoll- hyperque液分离淋巴细胞 ,1 2 5 Pindolol作为放射性配基进行受体结合分析 ,36例临界高血压患者血浆淋巴细胞β受体密度测定与 30例正常人血浆β受体密度测定比较。结果 :临界高血压患者淋巴细胞β受体密度高于正常血压组 ;β受体阻断剂 Atenolol干预后 ,可使临界高血压患者外周血淋巴细胞

Aim:To analyze the comparison of the density of β receptors of lyphocytes between 36 patients of critical hypertension and 30 normal healthy persons. Methods:Ficoll Hyperque liquid to separate lyphocytes. 125 I pindolol to be the radio ligand to combine the receptors.The PGI 2 were determined in before and after pindolol treatment. Results:The density of β receptors of lyphocytes was higher than the normal group.β receptors blockade can lower the density of β receptors of lymphocytes in critical hypertension after atenolol intervention.The beneficial increase of PGI 2 were observed after treatment