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claudin-7在胃癌细胞株和胃癌组织中表达及其临床意义 被引量：1

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摘要 目的探讨claudin-7在不同类型胃癌细胞株及胃癌组织中的表达及其与临床病理之间的关系。方法应用免疫组化检测claudin-7在SGC-7901细胞株、BGC823细胞株及10例正常胃黏膜,36例不典型增生胃黏膜及45例胃癌组织中的表达。结果正常胃黏膜、不典型增生胃黏膜及胃癌组织中,claudin-7阳性率呈递减趋势,组间差异性有统计学意义(χ2=9.630,P<0.01);claudin-7的表达与肿瘤的分化程度、浸润深度及有无淋巴结转移有关(P<0.05),而在性别和肿瘤大小组内差异无统计学意义(P>0.05)。结论 claudin-7的缺失与胃癌发生发展及浸润转移有关,有望成为反映胃癌生物学行为有价值的标志物。
作者 张俊会 鲁山 王秋兰 郭风振 李瑞玉
机构地区 邢台医学高等专科学校病理教研室 邢台市第三医院胸外科 甘肃中医学院临床医学系 邢台医学高等专科学校第二附属医院门诊部
出处 《中华临床医师杂志（电子版）》 CAS 2012年第9期192-194,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 胃肿瘤 免疫组织化学 claudin-7
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

  • 1张俊会,鲁山,王秋兰,郭风振,李瑞玉.claudin-7在胃癌细胞株和胃癌组织中表达及其临床意义[J].中华临床医师杂志（电子版）,2012,6(9):192-194. 被引量：1
  • 2Morin PJ. Claudin proteins in human cancer promising new targets for diagnosis and therapy. Cancer Res,2005 ,65 :9603-9606.
  • 3Soini Y, Tommola S, Helin H, et al. Claudin 1,3,4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse sub- type. Virchows Arch,2006,448:52-58.
  • 4Sawada N, Murata M, Kikuchi K, et al. Tight junctions and human dis- eases. Med Electron Micmsc ,2003,36 : 147-156.
  • 5Lee DB, Huang E, Ward HJ. Tight junction biology and kidney dys- function. Am J Physiol Renal Physio1,2006,290 : F20-34.
  • 6Sobel G, Paska C, Szabo I, et al. Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive caricinoma: Hum Patho1,2005,36 : 162-169.
  • 7Soini Y. Expression of claudins 1,2,5,4,5 and 7 in various types of tumours. Histopathology ,2005,46 : 551-560.
  • 8Tokes AM, Kulka J, Paku S,et al. Claudin-1 ,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res,2005,7 :R296-305.
  • 9Katoh M. CLDN23 gene, frequently downregulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Med, 2003,11:683-689.
  • 10Michl P, Barth C, Buchholz M, et al. Claudin-4 expression decrease in-vasiveness and metastatic potential of pancreatic cancer. Cancer Res, 2003,53:5265-5271.

二级参考文献11

  • 1Morin PJ. Claudin proteins in human cancer promising new targets for diagnosis and therapy. Cancer Res,2005 ,65 :9603-9606.
  • 2Soini Y, Tommola S, Helin H, et al. Claudin 1,3,4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse sub- type. Virchows Arch,2006,448:52-58.
  • 3Sawada N, Murata M, Kikuchi K, et al. Tight junctions and human dis- eases. Med Electron Micmsc ,2003,36 : 147-156.
  • 4Lee DB, Huang E, Ward HJ. Tight junction biology and kidney dys- function. Am J Physiol Renal Physio1,2006,290 : F20-34.
  • 5Sobel G, Paska C, Szabo I, et al. Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive caricinoma: Hum Patho1,2005,36 : 162-169.
  • 6Soini Y. Expression of claudins 1,2,5,4,5 and 7 in various types of tumours. Histopathology ,2005,46 : 551-560.
  • 7Tokes AM, Kulka J, Paku S,et al. Claudin-1 ,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res,2005,7 :R296-305.
  • 8Katoh M. CLDN23 gene, frequently downregulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Med, 2003,11:683-689.
  • 9Michl P, Barth C, Buchholz M, et al. Claudin-4 expression decrease in-vasiveness and metastatic potential of pancreatic cancer. Cancer Res, 2003,53:5265-5271.
  • 10Hoevel T, Macek R, Swisshelm K, et al. Reexpresion of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int Cancer,2004, 108:374-383.

同被引文献10

  • 1Morin PJ. Claudin proteins in human cancer promising new targets for diagnosis and therapy. Cancer Res,2005 ,65 :9603-9606.
  • 2Soini Y, Tommola S, Helin H, et al. Claudin 1,3,4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse sub- type. Virchows Arch,2006,448:52-58.
  • 3Sawada N, Murata M, Kikuchi K, et al. Tight junctions and human dis- eases. Med Electron Micmsc ,2003,36 : 147-156.
  • 4Lee DB, Huang E, Ward HJ. Tight junction biology and kidney dys- function. Am J Physiol Renal Physio1,2006,290 : F20-34.
  • 5Sobel G, Paska C, Szabo I, et al. Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive caricinoma: Hum Patho1,2005,36 : 162-169.
  • 6Soini Y. Expression of claudins 1,2,5,4,5 and 7 in various types of tumours. Histopathology ,2005,46 : 551-560.
  • 7Tokes AM, Kulka J, Paku S,et al. Claudin-1 ,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res,2005,7 :R296-305.
  • 8Katoh M. CLDN23 gene, frequently downregulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Med, 2003,11:683-689.
  • 9Michl P, Barth C, Buchholz M, et al. Claudin-4 expression decrease in-vasiveness and metastatic potential of pancreatic cancer. Cancer Res, 2003,53:5265-5271.
  • 10Hoevel T, Macek R, Swisshelm K, et al. Reexpresion of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int Cancer,2004, 108:374-383.

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中华临床医师杂志（电子版）
2012年 第9期

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