益生菌对功能性便秘的防治进展

Progress in the use of probiotics to prevent and treat functional constipation

随着饮食结构的改变及精神和社会压力的增大,便秘已成为困扰现代人的主要问题之一,严重影响着人们的生活质量.功能性便秘是指非全身疾病或肠道疾病引起的原发性持续性便秘,在不同人群中其发病率在2.0%-37.5%.传统的治疗功能性便秘的方式虽然安全可靠,且泻药能很快缓解便秘症状,但不能解决根本问题.因此,找寻一种安全有效的饮食或保健干预措施是非常必要的.便秘患者肠道微生态不同于健康人群,补充益生菌可改变这一现象.本文从介绍功能性便秘的发病现状入手,引入益生菌的概念,论述了益生菌防治便秘的机制、常用效应评价指标及目前的研究进展.

Due to the changes in diet structure and the increase in psychological and social pressure,constipation has become a very common health problem that seriously influences people＇s quality of life.Functional constipation（FC）is a kind of primary persistent constipation caused by non-systemic diseases or non-bowel diseases,with an incidence ranging from 2%to 37.5%.Although conventional treatments for FC are safe and reliable,and laxatives can quickly relieve constipation symptoms,they cannot resolve the fundamental problems.Therefore,it is essential to find a safe and effective diet or health care intervention for FC.The intestinal microecology of FC patients is different from that of healthy people,and the use of probiotics can help normalize intestinal function of FC patients.In this paper we discuss the recent progress in the use of probiotics to prevent and treat FC.