手足口病病原EV71和CA16的比较

Comparative analysis of EV71 and CA16 as pathogens of hand,foot and mouth disease

手足口病(Hand,foot and mouth disease,HFMD)是世界范围内流行的儿童传染病,曾在亚太地区出现过多次大规模的暴发和流行,肠道病毒71型(Enterovirus 71,EV71)和柯萨奇病毒A组16型(Coxsackie virus A16,CA16)是引起该病的两种主要病原。尽管这两种病毒在遗传学上关系很近,但其感染在临床表现和体征方面均存在一定差异,这种差异是源于病毒基因组的不同,还是由遗传表型特性所致,是值得研究的课题。本文就二者的特征及感染后宿主的细胞反应和比较蛋白质组学研究进行综述。

Enterovirus 71 （EV71） and Coxsackie virus A16 （CA16） are the main etiological agents of hand, foot and mouth disease （HFMD）, a common disease among children in worldwide which caused several large-scale outbreaks or epidemic in the Asia-Pacific Region. Although being genetically close to each other, there are some difference between EV71 and CA16 infections both in the clinical manifestations and signs. Whether the difference is due to the different viral genomes or genetic phenotype characteristics is worthy of study. In this paper, the characteristics of these two viruses, the cellular response after infection as well as comparative proteomics analyses are reviewed.