超声造影、磁共振评价肾射频消融短期效果的实验研究

Evaluation of the short-time effect of radiofrequency ablation on kidney by contrast-enhanced ultrasonography and magnetic resonance imaging

目的应用超声造影（CEUS）、磁共振（MRI）观察正常兔肾射频消融灶的影像表现，并与大体病理进行对照，探讨超声造影、MRI在正常肾射频消融效果评估中的价值。方法10只新西兰大白兔行肾经皮射频消融术，分别在射频术后1d、1周行超声造影及MRI检查，并与大体标本消融灶的测量结果进行比较。结果在射频消融术后较短时间内（术后1d和1周），超声造影和增强MRI可以清晰地显示肾消融灶的部位、形态及范围，影像表现与大体标本、超声造影与增强MRI测量结果比较，差异均无统计学意义（P〉0．05）。结论超声造影和增强MRI均适用于肾射频消融灶短期情况的观察评价，超声造影可以实时动态地显示消融灶血流灌注的变化。

Objective To evaluate the aeeuracy of the modalities in revealing the results by observing the radiofrequeney ablated （RFA） lesions with contrast-enhanced ultrasonography （CEUS）, magnetic resonance image （MRI） in comparison with histopathologic findings in normal rabbit kidney. Methods RFA was performed in the left kidneys of 10 rabbits. The ablated lesions were observed with conventional ultrasound（US） ,CEUS,MRI at 1 day, 1 week after RFA. Then the rabbits subjected to postmortem and the kidney specimens were excised,stained and processed for conventional histologic study. The maximum lesion size as measured on US,CEUS and MRI was then correlated with the histopathologically determined lesion size. The utility of different imaging modalities were evaluated. Results In a relatively short time （at 1 day and I week） ,CEUS and MRI may reveal the location, shape and extent of ablated lesion. And the lesion sizes with CEUS,MRI and kidney specimens were well correlated （ P 〉0.05）. Conclusions Both CEUS and MRI are suitable for the accurate evaluation of the ablated lesions in the short time. CEUS can reveal the variation of flow perfusion in the ablated lesion dynamicly and in real time.