p73 4G14C-4A14T基因多态性与结直肠癌发病风险相关性的系统评价

Systematic Review of Relationship between Genetic Polymorphism of p73 4G14C-4A14T and Susceptibility to Colorectal Cancer

目的系统评价细胞周期调控基因p73 4G14C-4A14T基因多态性与结直肠癌易感性的关系。方法检索2000—2010年Cochran图书馆、中国期刊网、中国生物医学文献数据库、维普科技期刊全文数据库、PubMed、Web of science、BIOSIS Preview、Journal Citation Reports、FMJS、EMMC等数据库,语种不限,获取有关p73 4G14C-4A14T基因多态性与结直肠癌发病风险相关性的研究结果,分别以病例组和对照组的p73 4G14C-4A14T基因型分布以及比值比(OR)为效应指标,确定纳入标准,对文献进行评价筛选,异质性检验,然后利用RevMan5.0软件对各研究原始结果进行统计处理,并计算合并的OR值及其95%可信区间。结果按照纳入标准,最终入选5篇文献,累计病例919例,对照1 234例。Me-ta分析p73 4G14C-4A14T基因型GC/GC vs.GC/AT+AT/AT合并OR值为0.84(95%CI:0.71～1.00),Z值为1.95,GC/GC vs.AT/AT合并OR值为0.50(95%CI:0.35～0.70),Z值为4.00,AT/ATvs.GC/GC+GC/AT合并OR值为1.94(95%CI:1.39～2.70),Z值为3.91。结论我们发现AT/AT基因纯合子可以明显提高结直肠癌的发病风险,差异有统计学意义,Meta分析结果说明p73 4G14C-4A14T基因多态性与结直肠癌发病风险之间有明显相关性。结果表明携带p73 4G14C-4A14T多态性是结直肠癌重要的发病因素。

Objective To evaluate the relationship between polymorphism of p73 4G14C-4A14T and susceptibility to colorectal cancer.Methods Studies from 2000—2010 were retrieved through Cochrane Library,Medline,Elsevier,Ovid,Highwire Press,PubMed,web of science,BIOSIS Preview,Journal Citation Reports,FMJS and EMMC database without language limitation to collect relevant papers.Odds ratio of p73 4G14C-4A14T genotype distributions in the group of patients with colorectal cancer and the group of healthy control was calculated.The Meta-analysis was applied with RevMan 5.0 software for Heterogeneity test and pooled OR calculation.Result Five case-control studies with 919 cases and 1234 controls were analyzed by fixed effects model（FEM） meta-analysis method.The pooled Odds Ratio of p734G14C-4A14T genotype GC/GC vs.GC/AT＋AT/AT was 0.84（95%CI：0.71~1.00）,Z statistics were 1.95,GC/GC vs.AT/AT was 0.50（95%CI：0.35~0.70）,Z statistics were 4.00.AT/AT vs.GC/GC＋GC/AT was 1.94（95%CI：1.39~2.70）,Z statistics were 3.91.Conclusion We found that the variant AT/AT homozygote was associated with a significantly increase risk of colorectal cancer.There was enough evidence currently to prove that there was a relationship between p73 4G14C-4A14T genetic polymorphism and susceptibility to colorectal cancer.It was demonstrated that the genetic polymorphism of p73 4G14C-4A14T was an important risk factor for susceptibility to human colorectal cancer.