金米益肺汤对非小细胞肺癌患者血清VEGF表达的影响

Effect of Jinmi Decoction on Concentration of Serum Vascular Endothelial Growth Factor in Non-small Cell Lung Cancer

目的研究金米益肺汤对非小细胞肺癌患者血清中VEGF水平的影响,并探讨其抗肿瘤作用机制。方法将60例非小细胞肺癌患者随机分为联合治疗组与化疗组,联合治疗组采用金米益肺汤联合化疗,化疗组采用单纯化疗,应用ELISA法测定两组患者治疗前后及20例健康体检人员血清中VEGF的表达。结果非小细胞肺癌患者血清中VEGF表达为(389.45±80.23)pg/ml,明显高于健康对照组(97.67±42.63)pg/ml,差异有统计学意义(P<0.01)。治疗后检测联合治疗组血清VEGF表达为(231.52±83.91)pg/ml,低于单纯化疗组(295.17±76.43)pg/ml,差异有统计学意义(P<0.05)。结论金米益肺汤可显著降低非小细胞肺癌患者血清VEGF的表达,提示金米益肺汤具有抗肿瘤血管形成作用。

Objective To investigate the effects of Jinmi decoction on the serum vascular endothelial growth factor（VEGF） in non-small cell lung cancer and its anti-tumor mechanism.Methods Sixty cases of non-small cell lung cancer were randomly divided into combination therapy group（Jinmi decoction ＋ chemotherapy） and chemotherapy group.The serum VEGF concentration was detected by ELISA in the two groups and in 20 normal controls.Results The serum VEGF concentration in non-small cell lung cancer was（389.45±80.23）pg/ml,higher than that in normal controls（P0.01）.The concentration of serum VEGF after therapy in combination therapy group was significantly lower than that in chemotherapy group（231.52±83.91）pg/ml vs..（295.17±76.43）pg/ml,（P0.05）.Conclusion Jinmi decoction could obviously reduce the concentration of serum VEGF and inhibit tumor angiogenesis in non-small cell lung cancer.