1Brigstock DR. The connective tissue growth factor/cysteine- rich 61/nephroblastoma overexpressed (CCN) family[J]. En- docr Rev,1999,20(2) :189-206.
2Kireeva ML, MO FE, Yang GP, et al. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion [J]. Mol Cell Biol, 1996,16(4) : 1326-34.
3Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloprotein- ases cleave connective tissue growth factor and reactivate an- giogenic activity of vascular endothelial growth factor 165[J]. Biol Chem,2002,277(39) :36288-95.
4Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins[J]. Int J Biochem Cell Biol, 2009,41 (4) :771-83.
5Menfindez JA, Mehmi I, Griggs DW, et al. The angiogenic factor CYR61 in breast cancer: molecular pathology and ther- apeutic perspectives[J]. Endocr Relat Cancer, 2003,10 (2) : 141-52.
6Aikawa T, Gunn J, Spong SM, et al. Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer[J]. Mol Cancer Ther, 2006,5(5) : 1108-16.
7Kang Y, Siegel PM, Shu W, et al. A multigenic program me- diating breast cancer metastasis to bone [J]. Cancer Cell, 2003,3(6) :537-49.
8Shimo T, Kubota S, Yoshioka N, et al. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer[J]. Bone Miner Res, 2006,21(7) : 1045-59.
9Tong X, Xie D, O'Kelly J,et al. Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer [J]. Biol Chem,2001,276(50) :47709-14.
10Chang CC, Shih JY, Jeng YM,et al. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metas- tasis[J]. J Natl Cancer Inst,2004,96(5) :364-75.
2kireeva M L, Mo F E, Yang J P, et al. Cyr61, a product Of a growth factor-inducible mmediate-early gene, promotes cell proliferation migration and adhesion[J]. Mol Cell Bio, 1996, 16(4) : 1326-1334.
3Bable A M, Kirceva M L, Kolesnikova T V, et al. Cyr61 a product of a growth fatter-inducible immediate early gene. promotes angiogenesis and tumor growth [ J ]. Proc Natl Acad Sci USA, 1998, 95 ( 11 ) : 6355-6360.
4Holloway S E, Beck A W, Girard L, et al. Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer[J]. J Am Coll Surg, 2005, 200(3) : 371-377.
5Gery S, Xie D, Yin D, et al. Ovarian carcinomas CCN genes are aberrantly expressed and CCNI promotes proliferation of these cells[J]. Clin Cancer Res, 2005, 11(20):7243-7254.
6Jay P, Berge-Lefranc J L, Marsollier C, et al. The human growth factor-inducible immediate early gene. CYR61, maps to chromosome 1p[J]. Oncogene, 1997, 14(14):1753-1757.
7Jiang W G, Watkins G, Fodstad O, et al. Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer [ J ]. Endocr Relat Cancer, 2004, 11(4) : 781-791.
8Menendez J A, Vellon L, Mehmi I, et al. A novel Cyr61-triggered' CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and Chemosensitivity through activation of ERKI/ ERK2 MAPK signahng pathway[J]. Oncogene, 2005, 24(5) : 761-779.
9Leu S J, Lain S C, Lau L F. Pro-angiogenic activities of Cyr61 (CCN1) mediated through integrins alphavbeta3 and alpha6betal in human umbilical vein endothelial cels[J]. J Biol Chem, 2002, 277(48) :46248-46255.
10Tong X, O'Klly J, Ie D, et al. Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc- p55 pathway[J]. Oncogene, 2004, 23(28):4847-4855.
3Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor[J].{H}FEBS Letters,1993,(02):125-130.
4Zuo G W,Kohls C D,He B C. The CCN proteins:important signaling mediators in stem cell differentiation and tumorigenesis[J].{H}Histology and Histopathology,2010,(06):795-806.
5Planque N,Perbal B. A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis[J].{H}Cancer Cell International,2003,(01):15.
6Rittié L,Perbal B,Castellot J J Jr. Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo[J].{H}Cell Communication and Signaling,2011,(01):69-80.
7Honjo T,Kubota S,Kamioka H. Promotion of Ccn2 expression and osteoblastic differentiationby actin polymerization,which is induced by laminar fluid flow stress[J].J Cell Commun Signal,2012,(04):225-232.
8Ohgawara T,Kubota S,Kawaki H. Association of the metastatic phenotype with CCN family members among breast and oral cancer cells[J].J Cell Commun Signal,2011,(04):291-299.
9Perbal B. NOV (nephroblastoma overexpressed) and the CCN family of genes:structural and functional issues[J].{H}Molecular pathology,2001,(02):57-79.
10Chien W,Kumagai T,Miller C W. Cyr61 suppresses growth of human endomet rial cancer cells[J].{H}Journal of Biological Chemistry,2004,(51):53087-53096.
