期刊文献+

乙型肝炎病毒与DNA甲基化研究进展 被引量:1

原文传递
导出
摘要 DNA甲基化(DNA methylation)属于表观遗传学的研究范畴。其主要发生在基因启动子区域的“CpG”岛部位。CpG岛双核苷酸中胞嘧啶第5位碳原子是甲基化的特异性位点。DNA甲基化是一个可逆的过程,不直接依赖于DNA序列。研究认为,它与基因表达调控、DNA修复、染色体稳定性及维持细胞正常分化等多种生命过程相关。
作者 王琦 成军
出处 《中华传染病杂志》 CAS CSCD 北大核心 2012年第4期254-256,共3页 Chinese Journal of Infectious Diseases
基金 基金项目:北京市卫生局青年科学研究资助项目(QN2008-009)
  • 相关文献

参考文献28

  • 1Park IY, Sohn BH, Yu E, et al. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology, 2007,132 : 1476-1494.
  • 2Zheng DL, Zhang L, Cheng N, et al. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol, 2009,50:377-387.
  • 3Vivekanandan P, Thomas D, Torbenson M. Hepatitis B viral DNA is methylated in liver tissues. J Viral Hepat, 2008,15:103-107.
  • 4Vivekanandan P, Thomas D, Torbenson M. Methylation regulates hepatitis B viral protein expression. J Infect Dis, 2009, 199:1286-1291.
  • 5Guo Y, Li Y, Mu S, et al. Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication. J Med Virol, 2009,81: 1177-1183.
  • 6Smith FM, Garfield AS, Ward A. Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res, 2006,113:279-291.
  • 7Yang B, Guo M, Herman JG, et al. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol, 2003,163: 1101-1107.
  • 8Feng O, Stern JE, Hawes SE, et al. DNA methylation changes in normal liver tissues and hepatoeellular carcinoma with different viral infection. Exp Mol Pathol, 2010,88: 287-292.
  • 9Nagai H, Baba M, Konishi N, et al. Isolation of NotI clusters hypomethylated in HBV-integrated hepatocellular carcinomas by two dimensional electrophoresis. DNA Res, 1999,6: 219-225.
  • 10Lee JO, Kwun HJ, Jung JK, et al. Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene, 2005,24 : 6617-6625.

二级参考文献6

  • 1Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR : a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A, 1996, 93: 9821-9826.
  • 2Macpherson AM, Archer DF, Leslie S, et al. The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium. Hum Reprod, 1999, 14: 3080-3087.
  • 3Shim YH, Yoon GS, Choi HI, et al. p16 hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis.Cancer Lett, 2003, 190: 213-219.
  • 4Li X, Hui AM, Sun L, et al. p16^INK4A hpermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma. Clin Cancer Res, 2004, 10: 7484-7489.
  • 5Lee JO, Kwun HJ, Jung JK, et al. Hepatitis B vires X protein represses E-cadherin expression via activation of DNA methyltransferase 1.Oncogene, 2005, 24: 6617-6625.
  • 6王兆文,彭志海,李克,裘国强,张益,顾炜.p16影响乙肝病毒相关性肝细胞肝癌的发生[J].中华肿瘤杂志,2003,25(4):356-358. 被引量:9

共引文献3

同被引文献3

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部