模拟失重对大鼠情绪影响的初步研究

Effects of simulated weightlessness on emotional behaviour in rats

目的:研究模拟失重状态对大鼠情绪产生的影响。方法:从20只雄性SD大鼠中挑选16只分成正常组和模拟失重组(n=8),采用摄食和体重测定、旷场试验、糖水偏好度测试及情绪唤醒程度评定四种方法,对大鼠进行情绪检测。结果:①模拟失重组大鼠摄食量下降,体重增加速率较正常组显著减小;②模拟失重14 d后,大鼠的运动力下降,爬格数显著低于正常组(P<0.05),自我修饰次数比正常组明显增多,洗脸与理毛次数均显著高于正常组(P<0.01);③与正常组比较,模拟失重大鼠具有更高水平的情绪唤醒度;④模拟失重14 d对大鼠的糖水偏好度无显著影响。结论:模拟失重14 d使大鼠出现抑郁、紧张和焦躁等负面情绪,出现一定程度的神经质反应,但不会出现快感缺乏。

Objective： To study the influence of 14- day simulated weightlessness on emotional behaviour in rats. Methods： Sixteen from twenty male SD rats were selected and assigned to a 2-group design： the control group and the tail suspension（TS） group （ n = 8）. The essay deployed typical methods for assessing emotional activity in the current, including food-intake and body weight variation, open field testing, su- crose preference testing and the evaluation of emotional arousal level to test emotional behavior. Results： （DAfter 14- day simulated weightlessness for rats, their food-intake and body weight increase were less than those in the control group. （2）The ability of movement reduced in rats, the number of locomotion was significantly lower than that in the control group（ P 〈 0.05） and the frequency of self-grooming was significantly higher than that in the control group（ P 〈 0.01）. （3）A higher level of emotionality in TS group was recorded. （4）Sucmse preference was not observed in TS group. Conclusion： It demonstrated depression, anxiety and nervous symptom occurred in the TS rats with a certain degree of nervous reaction but no anhedonia.