普萘洛尔联合1064nmNd：YAG激光治疗体表增殖期血管瘤的临床观察

The therapeutic effect of propranolol with 1 064 nm Nd ： YAG laser on proliferating hemangioma in body surface

目的评价普萘洛尔联合1064nmNd：YAG激光治疗体表增殖期血管瘤的疗效。方法97例体表增殖期血管瘤患儿，随机分为普萘洛尔与激光联合治疗组（A组，32例）、激光治疗组（B组，35例）和普萘洛尔治疗组（C组，30例）3组，分别比较3组患者治疗后的直观类比标度评分、整体疗效，以及不良反应等。结果治疗后第18周，A、B、c3组的直观类比标度评分平均分分别为65．50±16．55、54．03±20．13、28．08±30．34（P〈0．05）；第24周分别为76．88±19．05、63．89±19．43、45．48±31．86（P〈0．05）。治疗24周后，A、B、c3组中，分别有9例（28．1％）、3例（8．6％）、1例（4．0％）痊愈（P〈0．05）；皮肤不良反应的影响程度评分，B组高于A和c组（P〈0．05）。结论普萘洛尔联合1064nm Nd：YAG激光是治疗体表增殖期血管瘤的一种安全有效的方法。

Objective To observe the therapeutic effect of propranolol with 1 064 nm Nd：YAG laser on proliferating hemangioma in body surface. Methods 97 patients with proliferating hemangiomas in body surface were randomly assigned to three groups ：A group（32 patients were treated by propranolol with 1 064 nm Nd：YAG laser） ,B group（35 patients were treated by 1 064 nm Nd：YAG laser） , C group （30 patients were treated by propranolol）. Their visual analog scores, clinical outcomes and adverse events were compared respectively. Results 18 weeks later, A group had a mean visual analog score of 65.50 ± 16. 55 ,compared with 54. 03 ±20. 13 in B group, 28.08 ±30. 34 in C group（P 〈0. 05） ;24 weeks later, the mean visual analog scores of three groups were 76. 88 ± 19.05,63.89 ± 19.43 and 45.48 ± 31.86（P 〈 0.05）. After 24 weeks＇ treatment, 9 cases （ 28.1% ） in A group ,3 eases （ 8. 6% ） in B group ,1 cases （4. 0% ） in C group obtained complete healing（P 〈 0. 05 ）. To effect of adverse events in body surface, the mean score of B group was higher than the scores of A group and C group （P 〈 0.05 ）. Conclusions Propranolol with 1 064 nm Nd：YAG laser is effective and safe in the treatment of proliferating hemangioma.