1-(6-取代萘基-2)-1,2-二氢-2,2-二甲基-4,6-二氨基-1,3,5-三嗪的合成及抗癌作用(Ⅰ)

THE SYNTHESIS AND ANTICANCER ACTIVITY OF 1-(6-SUBSTITUTED NAPHTHYL-2)-1, 2-DIHYDRO-2,2-DIAMINO-1,3,5-TRIAZINES(Ⅰ)

本文报道了8个新的1(6-取代萘基-2)-1,2-二氢-2,2-二甲基-4,6-二氨基-1,3,5-三嗪及其原料6-取代-2-萘胺的合成。(Ⅴ)及(Ⅲ)用MGC-803胃腺癌细胞测定了抑制率及杀伤率。所有8个(Ⅴ)的抑制率均低于(Ⅲ),可能说明萘环上6-位取代对抗癌作用不利。

The synthesis of eight new l-(6-substituted naphthyl-2) -l,2-dihydro-2,2 -dimethyl-4,6 diamino-1,3,5-triatzines (Ⅴ) and their starting material, 6-substituted-2-naphthylamines have been reported. (Ⅴ) and (Ⅲ) have been tested their percentage of inhibition and percentage of killing of MGC-803 gastric carcinoma cell. The percentage of inhibition of (Ⅴ) are all lower than that of (Ⅲ). This probably means that 6-substituents on naphthalene ring are unfavorable to anticancer activity.