肝细胞癌的微环境研究进展

Status and Development of The Tumor Microenvironment in Hepatocellular Carcinoma

越来越多的研究表明,肿瘤细胞与其周围微环境的交互作用是肿瘤发生、上皮间质转化、肿瘤浸润和转移的关键调节因素.肝细胞癌的微环境可以分为细胞组分和非细胞组分.主要的细胞组分包含:肝星形细胞、肿瘤相关的纤维母细胞、免疫细胞和肝窦内皮细胞等.非细胞组分包含:胞外基质蛋白、酶类、各种生长因子和炎症因子等.综述了近年来肝细胞癌的微环境研究进展,分别从细胞组分和非细胞组分及其之间的相互作用角度对肝细胞癌微环境作一介绍.

A large quantity of literature highlights the interaction between tumor cells and the surrounding microenvironment which is a very important modulator of the processes in hepatocarcinogenesis.The microenvironment of hepatocellular carcinoma（HCC） can be obviously classified into cellular and produced non-cellular components,including hepatic stellate cells,tumor associated fibroblasts,immune cells and sinusoidal endothelial cells,extracellular matrix（ECM） proteins,growth factors and inflammatory cytokines which play an important role in the development and metastasis of HCC.In this review,we discuss the current cross-talk about the tumor microenvironment and tumor cells in pathogenesis of HCC.