8-OHdG在医学领域的应用与研究进展

Medical Application and Research Progress of 8-OHdG

氧化应激带来的氧化损伤是造成人体多种损伤和病变的重要因素。8-羟基脱氧鸟苷(8-hydroxy-2’-deoxyguanosine,8-OHdG)作为DNA氧化损伤产物是广泛用于研究疾病中氧化损伤机制的关键标志物。国内外大量研究已普遍应用8-OHdG作为分析指标,该文着眼于近年来研究动向,就8-OHdG的作用机理与检测方法,以及职业与环境暴露的危害评价、辅助疾病早期诊断、治疗和新药研发等方面的应用作一综述。

Oxidative damages caused by oxidative stress are key factors for a variety of human injuries and diseases. 8-hydroxy-deoxyguanosine （8-OHdG）, a product of oxidative DNA damage, is widely applied in studying the mechanisms of oxidative damage in various diseases. A large number of studies have used 8-OHdG as an analytical indicator. The present paper reviews the recent development of 8-OHdG focusing on its effect mechanisms, detection methods as well as its application in hazard assessment of occupational and environmental exposure, in early diagnosis of disease, and in development of new drugs.