重庆市成人血尿酸水平与代谢综合征相关因素分析

Correlation of serum uric acid level and metabolic syndrome in Chongqing adults

目的探讨血尿酸与代谢综合征(metabolic syndrom e,MS)各组分之间的相关性及相关程度。方法选取2010年在本院参加体检的主城区居民79 092例,年龄18～95岁,其中男性45 495例,女性33 597例,测定血尿酸、体质量指数、腰围、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇等水平,分析血尿酸与各指标的相关性。结果男性高尿酸血症患病率明显高于女性(男性22.19%,女性6.05%,P<0.01);男女组的体质量指数、腹围、收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇与血尿酸水平呈正相关(P<0.05),而与高密度脂蛋白胆固醇则呈负相关(P<0.01);血尿酸水平与MS患病风险性密切相关。无论男女,随着血尿酸水平的升高,MS患病率逐渐增加。结论血尿酸水平与MS密切相关,控制血尿酸水平是预防M S的发生及降低心血管事件风险的重要环节之一。

Objective To investigate the correlation between serum uric acid（SUA） level and the indicators of metabolic syndrome（MS） among the adults of Chongqing,China.Methods The levels of SUA,body mass index（BMI）,waist circumference（WC）,systolic pressure（SBP）,diastolic pressure（DBP）,fasting blood glucose（FBG）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-c） and low-density lipoprotein cholesterol（LDL-c） were measured in 79 092 physically examined residents（male 45 495 and female 33 597;18 to 95 years old） in our hospital during 2010.Results The prevalence of hyperuricemia was significantly higher in the male adults than in the female adults（22.19% vs 6.05%,P0.01）.The SUA level was positively correlated with the levels of BMI,WC,SBP,DBP,TC,TG and LDL-c（P0.05）,but negatively correlated with the HDL-c level in both the male and female adults（P0.01）.There was a significantly positive correlation between the SUA level and the MS prevalence,which increased along with the increase of SUA level in both the male and female adults.Conclusion There is a positive correlation between the SUA level and MS.Controlling SUA level is important for preventing the occurrence of MS and reducing the risk of cardiovascular events.