自拟抗敏止咳方治疗咳嗽变异型哮喘42例

Treatment of cough variant asthma by "Kangmin Zhike Decoction":report of 42 cases

目的观察抗敏止咳方治疗咳嗽变异型哮喘的临床疗效。方法将82例咳嗽变异型哮喘患者随机分为治疗组、对照组。对照组40例予西医常规治疗,治疗组42例在西医常规治疗基础上予以抗敏止咳方煎剂口服;两组均治疗3周,观察临床疗效及咳嗽症状减轻、消退及夜间咳嗽消失时间,并于结束治疗后6个月随访复发率。结果治疗组、对照组总有效率分别为90.47%、70.00%;组间临床疗效比较,差异有统计学意义(P<0.05)。在结束治疗后的6个月中,治疗组、对照组复发率分别为11.90%、40.00%;组间复发率比较,差异有统计学意义(P<0.01)。治疗组咳嗽症状减轻、消退及夜间咳嗽消失时间与对照组比较,差异有统计学意义(P<0.01)。结论抗敏止咳方治疗咳嗽变异型哮喘临床疗效良好。

Objective To observe the clinical efficacy of ＂Kangmin Zhike Decoction＂ for cough variant asthma（CVA）.Methods Eighty-two subjects were randomized into two groups： control group in which 40 cases were treated with routine therapy,while the treatment group in which 42 cases were treated with ＂Kangmin Zhike Decoction＂ and routine therapy,with the course of 3 weeks.The clinical efficacy,symptoms of cough ease and relief times at night were observed.Recurrence rate was observed after 6 months＇ follow-up.Results The total effective rate was 90.47% in treatment group and 70.00% in control group.The difference of the clinical effective rate between the two groups was statistically significant（P0.05）.At the end of the 6 months＇ follow-up,the recurrence rate was 11.90% and 40.00% in treatment group and in control group respectively.The difference of the recurrence rate between the two groups was statistically significant（P0.01）.The cough relife,cough disapperance,and the at night time without coughing all were better in the treatment group than in the control group（P0.01）.Conclusion ＂Kangmin Zhike Decoction＂ is effective for cough variant asthma.