摘要
目的探讨促红细胞生成素(erythropoietin,Epo)对兔心肌缺血再灌注的保护作用。方法建立兔心肌缺血再灌注损伤模型,选用新西兰兔30只随机分为对照组、缺血组、Epo治疗组,检测血浆丙二醛(MDA)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)和心脏组织匀浆超氧化物歧化酶(SOD)、白介素-6(IL-6)变化。结果 Epo治疗组血浆MDA、CK、CK-MB、cTnT水平较缺血组显著下降(P<0.05);心脏组织匀浆SOD显著升高、IL-6显著降低(P<0.05)。结论 Epo对兔心肌缺血再灌注损伤具有保护作用,这种作用可能与提高心脏组织中SOD水平,降低心脏组织中IL-6水平有关。
Objective To study the protective effect of erythropoietin on heart ischemia /reperfusion（I/R）injury in rabbits.Methods The model was made by ligating the left desceding coronary artery for 45 minutes and reperfusing for 1 hour in rabbits.30 rabbits were divided into control group,ischemia group and Epo group.Epo was used on the rabbits at the beginning of reperfusion.Plasma MDA,CK,CK-MB,cTnT and tissue SOD,IL-6 were observed.Results Plasma MDA,CK,CK-MB,cTnT and tissue IL-6 of Epo group were significantly lower than those ischemia group.SOD in heart tissue was significantly higher.Conclusion Our results indicate that Epo has a protective effect on heart ischemia/reperfusion injury in rabbits because it can increase SOD in heart tissue,decrease IL-6 in heart tissue.
出处
《四川医学》
CAS
2012年第4期589-591,共3页
Sichuan Medical Journal
