摘要
目的研究苦参碱类衍生物13α-甲氧基苦参碱的合成及其杀菌效果。方法采用实验室合成工艺和悬液定量杀菌试验以及现场模拟消毒试验等方法,对该物质进行了实验室合成和杀菌效果观察。结果用本实验室建立的合成工艺,成功合成了13α-甲氧基苦参碱固体粉剂。以含20 g/L浓度的13α-甲氧基苦参碱甲醇水溶液对悬液内大肠杆菌作用20 min,40 g/L对金黄色葡萄球菌作用40 min和对枯草芽孢杆菌黑色变种作用60 min,平均杀灭率均达99.9%以上。用上述浓度的该溶液,以30 ml/m3用量对室内进行气溶胶喷雾并作用30 min,可使空气中自然菌的消除率达到90%以上。结论实验室建立的13α-甲氧基苦参碱合成工艺成功,该化合物对细菌繁殖体具有较好杀灭效果,值得进一步研究。
Objective To study the synthesis and disinfection effect of 13α-methoxy matrine.Methods With the laboratory synthetic process,suspension quantitative germicidal test and field simulated disinfection test were used to observe the bactericidal effect of 13α-methoxy matrine in the laboratory.Results With the establishment of the laboratory synthetic process,13α-methoxy matrine solid powder was successfully synthesized.The germicidal rate was above 99.9% when Escherichia coli exposed to 13α-methoxy matrine(20 g/L) for 20 minutes,Staphylococcus aureus to 40 g/L for 40 minutes and Bacillus subtilis var niger for 60 minutes respectively.Use the above solution of the same concentration at a dosage of 30 ml/m3,the disinfection rate of the closed room air disinfection test was above 90% to the natural bacterium in the air for 30 minutes.Conclusion 13α-methoxy matrine synthesized successfully in the laboratory had good disinfection effect to the bacterial,and it was deserved to be further studied.
出处
《中国消毒学杂志》
CAS
北大核心
2012年第5期376-378,381,共4页
Chinese Journal of Disinfection
基金
中国检验检疫科学研究院基本科研业务费专项资金(2011JK006)