正畸复发过程中大鼠磨牙龈沟液IL-6水平的改变

The change of Levels of IL-6 in gingival crevicular fluid after removal of orthodontic forces

目的:研究正畸复发过程中大鼠磨牙龈沟液中I L-6水平的变化。方法:将20只Wi s t ar雄性大鼠上颌右侧第一磨牙建立正畸牙齿移动模型,装置安装10天后去除,分别收集安装装置前及装置去除后第4天、第8天、第12天的右上颌第一磨牙龈沟液,ELI SA法检测各时间段龈沟液中I L-6的含量,并将所测结果进行统计学分析。结果:去除装置后第4天大鼠磨牙龈沟液中I L-6水平高于其余3组,P都小于0.05;去除装置后第8天与第12天I L-6水平相差不多,且P>0.05;而这两组I L-6水平分别高于未安装装置前的水平,P都小于0.05。结论:正畸复发对大鼠磨牙龈沟液中I L-6水平有影响。

Objective To investigate the levels of IL-6 in gingival crevicular fluid （GCF）of the rat molar after the removal of orthodontic forces. Methods Twenty Wistar male rats were installed with orthodontic teeth movement devices. Ten days later the devices were wiped off. The GCF of maxillarY first molar was collected on the fourth,eighth and twelveth days after the devices were put off. The GCF was also Collected before the equipments were fixed. ELISA was used to detect the levels of IL-6 and the results processed statistical analysis. Results Device removal after 4th day,the levels of IL-6 were the highest of all the groups （P〈0.05）. While the levels in the 8th day and the 12th day have similar resultant values （P〉0.05）. And the levels of IL-6 before the devices installed were lower compared with the 8th day and the 12th day （P〈0.05）. Conclusion Orthodontic relapse has influence on the levels of IL-6 in GCF from rat molar.