添加黄芪的肠内营养对部分结肠切除大鼠抗氧化的影响

Effects of early total enteral nutrition with astragalus on ability of anti-oxidation in postoperative mouse with partial colectomy

目的:研究早期肠内营养(EEN)液中添加黄芪,对部分结肠切除大鼠术后抗氧化的影响。方法:将20只大鼠随机分为两组,即实验组(术后添加黄芪EN组),对照组(术后EN组)。分别于实验开始后第11天取静脉血2 ml,测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-PX)。结果:实验组大鼠血清SOD和GSH-PX含量显著高于对照组(P<0.05),血清MDA含量显著低于对照组(P<0.05)。结论:术后早期给予添加黄芪的EN液,有利于部分结肠切除大鼠术后氧自由基的清除,提高抗氧化作用。

Objective： To study the effects of early total enteral nutrition with astragalus on ability of anti-oxidation in rats after partial colectomy.Methods： 20 SD rats with partial colectomy were randomly divided into 2 groups.10 rats were fed with total enteral nutrition added astragalus（experiment group,n=10）,and other group was fed with total enteral nutrition（comparison group,n=10）.Superoxide Dismustase（SOD）,Malondialdehyde（MDA） and Glutathione-Peroxidase（GSH-PX） were measured 11 days after the operation respectively.Results： SOD and GSH-PX in serum in experiment group were higher significantly（P0.05） compared with those in comparison group.MDA in blood serum in experiment group was less significantly（P0.05） compared with those in comparison group.Conclusion： Effects of early total enteral nutrition added asgaralus was benefit in anti-oxidation in postoperative rats with partial colectomy.