PSGL-1在Apc^(Min/+)小鼠肠道肿瘤发生中的作用

The role of PSGL-1 in the growth of intestinal tumor in Apc^(Min/+) mice

目的研究P-选凝素糖蛋白配体1(P-selectin glycoprotein ligand 1,PSGL-1)在ApcMin/+小鼠肠道肿瘤中的作用。方法PSGL-1基因缺失的基因工程小鼠和肠道肿瘤模型ApcMin/+小鼠杂交后,统计ApcMin/+小鼠与(ApcMin/+;PSGL-1-/-)杂交小鼠小肠及大肠肿瘤的数目和总负荷,观测其肠道肿瘤的发生变化。结果相比ApcMin/+小鼠,(ApcMin/+;PSGL-1-/-)杂交小鼠在18周龄时肠道肿瘤数目与总负荷有明显增加。结论 PSGL-1的缺失促进了ApcMin/+小鼠肠道肿瘤的发生,PSGL-1在人类肠道肿瘤中可能发挥着抑制肿瘤形成的作用。

Purpose To investigate the role of P-selectin glycoprotein ligand 1 （ PSGL-1 ） in ApcMin/＋ mice intestinal tumors. Methods ApeMiKe＋ was crossed with PSGL-l-deficient mice and the tumor susceptibility in intestine was compared. The small intestine and co- lon tumor number and the total tumor volume of ApcMin/＋ mice and ApcMin/＋ , PSGL-1 -/- mice were analyzed and the changes in intestinal tumor were observed. Results PSGL-1 deficiency in ApeMin/＋ mice resulted in significant increase of tumor numbers and tumor vol- umes in the small intestine and total intestine at 18 weeks. Conclusion These findings have provided the genetic evidence for a tumor suppression role of PSGL-1 in the intestine of mice. Importantly, these studies also suggest that PSGL-1 may be a tumor suppressor for human intestinal tumors.