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大黄素抑制Lovo细胞迁移与黏附的作用 被引量：2

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摘要 目的探讨大黄素对lovo细胞与内皮细胞迁移和黏附的影响。方法采用MTT法检测大黄素对Lovo细胞和HUVECs增殖的影响,分光光度法检测大黄素对Lovo细胞与HUVECs黏附的影响,Transwell双层小室观察大黄素对Lovo细胞迁移穿过单层HUVECs的影响。结果与对照组比较,10～40μmol/L大黄素对Lovo细胞和HUVECs增殖无显著性影响(P>0.05);与对照组比较,大黄素能够降低Lovo细胞与内皮细胞的黏附(P<0.05),并显著减少迁移与穿过单层HUVECs的Lovo细胞数目(P<0.05)。结论大黄素具有抑制肿瘤细胞与内皮细胞的黏附以及肿瘤细胞迁移穿过内皮细胞的作用,提示其具有抗肿瘤转移的潜能。
作者 张春 韩丽君 董海影 李智勇 常星 兴桂华
机构地区 齐齐哈尔医学院中心实验室 齐齐哈尔市中医医院 青岛农业大学动物科技学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第10期2087-2088,共2页 Chinese Journal of Gerontology
基金 黑龙江省教育厅资助项目(No.11551554)
关键词 大黄素 黏附 肿瘤转移 迁移
分类号 R28 [医药卫生—中药学]
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参考文献8

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共引文献11

同被引文献40

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中国老年学杂志
2012年 第10期

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