性别对抗抑郁药物药动学的影响

Effects of sex difference on pharmacokinetics of antidepressants

抗抑郁药物治疗存在性别差异,药动学的性别差异是抗抑郁药物作用个体差异的主要因素之一。抗抑郁药的吸收、分布、代谢、排泄均在一定程度上受到性激素的影响。药动学结果表明女性比男性对抗抑郁药有更多的暴露,女性应接受较低剂量的抗抑郁药,但此建议只有在基因多态性和激素显著改变了对抗抑郁药的暴露,影响治疗的成功性时才采用。近年来关于抗抑郁药药动学性别差异的研究取得了较大的进展,本文综述了相关领域的研究结果。

Sex difference has been identified in antidepressant treatment and it is one of the major factors causing interindividual differences in antidepressant treatment. Absorption, distribution, metabolism and excretion of antidepressants are all influenced to some extent by gonadal hormones. Pharmacokinetic evidence indicates a greater exposure of women to antidepressants. It suggests that women should receive lower doses of antidepressants. However, this general recommendation should only be taken given that genetic polymorphisms and hormonal effects significantly alter the expected exposure to antidepressants. In recent years, great progress has been achieved in the study on sex difference in pharmacokinetics of antidepressants. The recent results in this area were reviewed in this paper.